Riboflavin (Vitamin B2)

Also known as: Lactoflavin, Vitamin G

Drug #648

Riboflavin (Vitamin B2) is a water soluble vitamin comprising a substituted isoalloxazine ring system linked to ribitol. It was formerly knowns as vitamin B2 or G and lactoflavin. The riboflavin requirement is related to energy intake and is essential for the utilisation of energy from food but it appears to be more closely related to resting metabolic requirements. Riboflavin (Vitamin B2) is also necessary for the functioning of pyridoxine (vitamin B6) and nicotic acid. Important food sources are liver, kidney, fish, milk, eggs, cheese, yeast and some green vegetable such as broccoli and spinach. Riboflavin (Vitamin B2) is administred orally or parentrally.

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Primary Characteristics

Riboflavin (Vitamin B2) is also known as Lactoflavin, Vitamin G.

It is of Synthetic origin and belongs to Isoalloxazine.

It is classified in Vitamin, Water Soluble pharmacological group.

Molecular Weight: 376.4 · pK_a: 1.9, 10.2 · Solubility in Water: 1 in 3000 - 20000 · Solubility in Alcohol: < 1 in 10000 · Non-proprietary name: Riboflavin (Vitamin B2).

Molecular structure of Riboflavin (Vitamin B2)

Pharmacokinetics

Absorption: Riboflavin (Vitamin B2) has an oral bioavailability is 60.5% (±9.5%).

Distribution: Riboflavin (Vitamin B2) has a plasma protein binding is 60 %.

Elimination: it is metabolised via Hepatic, plasma half-life is 1 hr, renal excretion is unchanged.

Indications

Riboflavin (Vitamin B2) is primarily indicated in conditions like Arabinoflavinosis, Vitamin deficiency.

Riboflavin (Vitamin B2) is also indicated for secondary conditions like Migraine prophylaxis.

Contraindications

Riboflavin (Vitamin B2) is contraindicated in conditions like Cataract, Hypersensitivity to any component of product.

Dosage

Riboflavin (Vitamin B2)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
0.02 mg/ kg	0.02 mg/ kg	Every 24h	IV
6 mg	6 mg	Every 24h	PO	for arabinoflavinosis
15.5 mg	15.5 mg	Every 24h	PO	for vitamin deficiency
Paediatric Dosage (20kg)
1 mg	1 mg	Every 24h	Oral	for infants
Neonatal Dosage (3kg)
1 mg/kg	1 mg/kg	Every 24h	Oral	-

Drug Interactions

15 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Riboflavin (Vitamin B2) is known to cause more or less tolerable side effects which are usually transient. These include Difficulty breathing, Discoloration of urine, Swelling of face, Swelling of lips and tongue.

Warnings / Precautions

Avoid use of large dose of riboflavin because it may result in bright yellow discoloration of the urine, which may interfere with certain lab tests.

Available Brands

Click on a strength to view available brands.

Multi-Ingredient Combinations

Caps

0.5 mg 3 mg 5 mg

Caps

1 mg 10 mg 15 mg 2 mg 3.4 mg 8 mg

Dragees

15 mg 5 mg

Dragees

2 mg

Drops

0.4 mg/0.6ml 1.2 mg/0.6ml 3 mg/ml

Eye Oint

0.3 g

Inf

10 mg/10ml 2 mg/ml 2.5 mg/L

Inj

1 mg/ml 2 mg/ml 4 mg/ml

Inj

Liquid

Sachet

Soft Caps

Susp

Syrup

0.153 mg/ml 0.4 mg/5ml 0.616 mg/5ml 1.5 mg/5ml 2 mg/5ml 3.33 mg/5ml 30 mg/5ml 6 mg/5ml

Tabs

0.5 mg 0.85 mg 1 mg 1.2 mg 1.5 mg 1.6 1.6 mg 1.7 mg 1.8 mg 10 mg 100 mg 12 mg 15 mg 2 mg 2.5 mg 2.6 mg 3 mg 3.2 mg 3.3 mg 3.4 mg 5 mg 6 mg 8.5 mg

Tabs Chewable

0.8 mg

Tabs efr

5 mg

Storage Conditions

Riboflavin (Vitamin B2) should be stored Syrup, Caps.

Drug Classification

1.27 — Vitamins, minerals, tonics, and other susbstances