Promazine (HCl)

Drug #622

Promazine (HCl) is antipsychotic belongs to phenothiazine. Promazine (HCl) is used to treat manifestation of psychotic disorder. Promazine (HCl) is effective for the control of nausea and vomiting and for reducing agitation and tension associated with mild alcohol withdrawal.

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Primary Characteristics

It is of Synthetic origin and belongs to Phenothiazine .

It belongs to D2 antagonist pharmacological group on the basis of mechanism of action and also classified in Hypnotic, Sedative pharmacological group. It is also classified under Psychotherapeutic Drugs .

Molecular Weight: 320.9 · pK_a: 9.4 · Solubility in Water: 1 in 2 · Solubility in Alcohol: 1 in 2 · Non-proprietary name: Promazine (HCl).

Pharmacokinetics

Distribution: Promazine (HCl) has a volume of distribution is . plasma protein binding is .

Elimination: it is metabolised via , plasma half-life is , renal excretion is 33% .

Indications

Promazine (HCl) is primarily indicated in conditions like Adjunct to analgesia, Agitation, Alcohol withdrawal, Insomnia, Intractable hiccup, Muscle spasm of varied aeitology, Psychomotor agitation.

Contraindications

Promazine (HCl) is contraindicated in conditions like Coma, Narrow-angle glaucoma.

Dosage

Promazine (HCl)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
75 mg	75 mg	Every 8h	IM	Frequency may be increased upto 4 times/day if needed.
2.14 mg	2.14 mg	Every 6h	PO	Frequency may be increased upto 6 times/day if needed.
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown10 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Promazine (HCl) in overdosage may give rise to further complications which include Abnormal liver function , Arteriolar spasm , Extrapyramidal symptoms, Gangrene , Obstructive jaundice , Parkinsonism , Thrombophlebitis .

Promazine (HCl) produces potentially life-threatening effects which include Agranulocytosis, Leucopenia . Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Promazine (HCl) are Coma, Seizures, Hallucinations , Ataxia, Respiratory depression, Grand Mal Seizures (epilepsy), Restlessness , Sedation , Excitation , Rapid fall in BP, CNS excitation, Anxiety , Sleepiness, Deep sleep, Akathisia .

Promazine (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Blurred vision, Breast enlargement, Confusion, Constipation , Drowsiness, Dry mouth, Epilepsy, Hypotension , Nasal congestion , Postural hypotension, Tachycardia, Urinary hesitancy.

Warnings / Precautions

Promazine should be used with caution in patients exposed to extreme heat or phosphorus insecticides, patients in state of alcohol withdrawal, patients with history of peptic ulcer, allergic reactions, with renal (kidney) impairment, prostatic hypertropy. Photosensitization may occur, caution patients against exposure to sunlight or UV light. Discontinue use atleast 48 hr before myelography.

Interference in Pathology

Promazine (HCl) may interfere in the diagnosis of Estimation of alkaloids,barbiturates,17-ketosteroids,17-hydroxycorticosteroids in urine. , Estimation of 5-hydroxyindoleacetic acid,protein & salicylates in urine. .

Available Brands

Click on a strength to view available brands.

Single Ingredient

Syrup

5 mg/5ml

Storage Conditions

Promazine (HCl) should be stored Tab, Susp, Soln, IV Inj, IM Inj.

Drug Classification

1.24.3 — Drugs used in anxiety and sleep disorders

Manufacturers

Manufacturers of Promazine (HCl) in Pakistan:

Ardin