Oxprenolol (HCl)
Oxprenolol (HCl) is a non-selective ß receptor blocking agent with some partial agonist activity. Chemically Oxprenolol (HCl) is 1-[2-(allyloxy) phenoxy]-3-isopropylaminopropan-2-ol hydrochloride. Oxprenolol (HCl) is antihypertensive agent and used in the management of hypertension, angina pectoris, also in anxiety disorders.
Primary Characteristics
It is of Synthetic origin and belongs to Benzene.
It belongs to Beta adrenergic antagonist pharmacological group on the basis of mechanism of action and also classified in Antihypertensive Agents pharmacological group.
Molecular Weight: 301.8 · pKa: 9.5 · Solubility in Water: high · Solubility in Alcohol: high · Non-proprietary name: Oxprenolol (HCl).
Pharmacokinetics
Absorption: Oxprenolol (HCl) has an oral bioavailability is 100%, pre-systemic (first-pass) metabolism accounts for 52.5%.
Distribution: Oxprenolol (HCl) has a volume of distribution is 1.3 l/kg. plasma protein binding is 75 %.
Elimination: it is metabolised via Hepatic, plasma half-life is 1.9 hr, renal excretion is > 95 %.
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Indications
Oxprenolol (HCl) is primarily indicated in conditions like Angina, Cardiac arrhythmia, Hypertension, Obstructive cardiomyopathy, To prevent 1st occurrence of neural tube defect, To prevent recurrence of neural tube defect.
Oxprenolol (HCl) is also indicated for secondary conditions like Anxiety.
Contraindications
Oxprenolol (HCl) is contraindicated in conditions like Bronchospasm, Cardiac failure, Haemorrhage, Bradycardia, Low cardiac output.
Dosage
Oxprenolol (HCl)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 1.285 mg/kg | 1.285 mg/kg | Every 8h | PO | - |
| Paediatric Dosage (20kg) | ||||
| 1 mg/kg | 1 mg/kg | Every 8h | Oral | - |
| Neonatal Dosage (3kg) | ||||
| 1 mg/kg | 1 mg/kg | Every 8h | Oral | - |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Oxprenolol (HCl) produces potentially life-threatening effects which include Bradycardia , Hypoglycemia , Hypotension, Bronchospasm . Careful monitoring is needed with proper medical management.
Oxprenolol (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Coolness of extremities, Lethargy, Wheezing .
Warnings / Precautions
Interference in Pathology
Oxprenolol (HCl) may interfere in the diagnosis of False +ve Fluorometric Readings in Urine Cortisol Determination .
Available Brands
None recorded.
Storage Conditions
Drug Classification
- 1.12.3.1 — Beta blocking agents