Noradrenaline (Acid Tartrate)

Also known as: Norepinephrine

Drug #522

Noradrenaline (Acid Tartrate) is a naturally occuring catecholamine, a neurohormone released by the postganglionic adrenergic nerves and some brain neurons. Noradrenaline (Acid Tartrate) is a powerful vasoconstrictor. It causes an increase in blood pressure and used to support blood pressure in acute hypotensive states.

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Primary Characteristics

Noradrenaline (Acid Tartrate) is also known as Norepinephrine.

It is of Natural origin and belongs to Catecholamine.

It belongs to Alpha adrenergic agonist pharmacological group on the basis of mechanism of action and also classified in Vasoconstrictor pharmacological group. It is also classified under Drugs used in Shock .

Molecular Weight: 337.3 · pK_a: 8.6, 9.8, 12 · Solubility in Water: 1 in 2.5 · Solubility in Alcohol: 1 in 300 · Non-proprietary name: Noradrenaline (Acid Tartrate).

Molecular structure of Noradrenaline (Acid Tartrate)

Pharmacokinetics

Absorption: Noradrenaline (Acid Tartrate) has an oral bioavailability is 60.5% (±9.5%), pre-systemic (first-pass) metabolism accounts for 97% (±2%).

Distribution: Noradrenaline (Acid Tartrate) has a volume of distribution is 0.09 - 0.40 l/kg. plasma protein binding is 50 %.

Elimination: it is metabolised via extensive by Liver, plasma half-life is 1.75 min, renal excretion is extensive.

Indications

Noradrenaline (Acid Tartrate) is primarily indicated in conditions like Acid-related dyspepsia, Cardiac arrest, Hypotension, Shock.

Noradrenaline (Acid Tartrate) is also indicated for secondary conditions like Local anaesthesia, Local anaesthetic.

Contraindications

Noradrenaline (Acid Tartrate) is contraindicated in conditions like Hypertension, Hyperthyroidism, Myocardial infarction, Ischaemic heart disease.

Dosage

Noradrenaline (Acid Tartrate)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
2 – 4 µg/min	—	—	IV Inf	Maintenance Dose
8 – 12 µg/min	—	—	IV Inf	Initial Dose
Paediatric Dosage (20kg)
0.15 ug/kg.min	0.15 ug/kg.min	—	IV Infusion	Maintenance , As required
0.2 ug/kg.min	0.2 ug/kg.min	—	IV Infusion	Initial , .As Required
Neonatal Dosage (3kg)
0.15 ug/kg.min	0.15 ug/kg.min	—	IV Infusion	Maintenance , As required
0.2 ug/kg.min	0.2 ug/kg.min	—	IV Infusion	Initial , .As Required

Drug Interactions

Unknown25 interactions

Moderate2 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Noradrenaline (Acid Tartrate) in overdosage may give rise to further complications which include Gangrene , Local necrosis , Sloughing .

Noradrenaline (Acid Tartrate) produces potentially life-threatening effects which include Cerebral hemorrhage, Pulmonary edema , Hypertension. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Noradrenaline (Acid Tartrate) are Headache, Sweating , Pallor, Photophobia, Severe hypertension, Retrosternal pain.

Noradrenaline (Acid Tartrate) is known to cause more or less tolerable side effects which are usually transient. These include Anxiety, Bradycardia , Headache, Palpitation.

Warnings / Precautions

Infuse noradrenaline into large vein to avoid necrosis & sloughing. Dangerously high B.P may produced with overdoses, so monitor B.P after every two min. from the time of administration until desired B.P is obtained, then after every five min. administration is to be continued. Its use is not a substitute for the replacement of blood, plasma, fluid & electrolytes. .

Available Brands

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Single Ingredient

Inj

1 mg/ml

Storage Conditions

Noradrenaline (Acid Tartrate) should be stored Inj.

Drug Classification

1.12.8 — Other cardiovascular preparations

Manufacturers

Manufacturers of Noradrenaline (Acid Tartrate) in Pakistan:

Ontech