Nicoumalone
Also known as: Acenocoumarol , acenoc(o)umarin
Nicoumalone is an anticoagulant, with actions, interactions and adverse effects similar to warfarin.
Primary Characteristics
Nicoumalone is also known as Acenocoumarol , acenoc(o)umarin.
It is of Semi Synthetic origin and belongs to Coumarin.
It belongs to Epoxide Reductase inhibitor pharmacological group on the basis of mechanism of action and also classified in Anticoagulants pharmacological group.
Molecular Weight: 353.3 · Solubility in Alcohol: 1 in 400 · Non-proprietary name: Nicoumalone.

Pharmacokinetics
Absorption: Nicoumalone has an oral bioavailability is 83% (±7%).
Distribution: Nicoumalone has a volume of distribution is 0.3 l/kg. plasma protein binding is 98 %.
Elimination: it is metabolised via extensive, plasma half-life is 8 hr, renal excretion is 60 %.
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Indications
Nicoumalone is primarily indicated in conditions like Deep vein thrombosis, Duodenal errosions, Myocardial infarction, Prevention of thrombosis, Prophylaxis of embolisation, Prosthetic heart valves, Pulmonary embolism, Rheumatic heart disease.
Contraindications
Nicoumalone is contraindicated in conditions like Haemorrhage, Cerebrovascular disease.
Dosage
Nicoumalone's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 4 – 12 mg | — | Every 24h | PO | Initial, Reduce dose on second day |
| 1 – 8 mg | — | — | PO | Maintenance, As required |
| Paediatric Dosage (20kg) | ||||
| 0 – 0 | — | — | Not recommended for this age group | |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Nicoumalone in overdosage may give rise to further complications which include Skin necrosis .
Nicoumalone produces potentially life-threatening effects which include Hemorrhage , GI bleeding, Hematuria, Bruising , Hemorrhage. Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Nicoumalone are Bleeding .
Warnings / Precautions
Interference in Pathology
Nicoumalone may interfere in the diagnosis of Urinanalysis , Increased values of hepatic enzymes.
Available Brands
None recorded.
Storage Conditions
Drug Classification
- 1.10.2 — Anticoagulants/Platelet deaggregators