DrugInfoSys

Nicoumalone

Also known as: Acenocoumarol , acenoc(o)umarin

Drug #514

Nicoumalone is an anticoagulant, with actions, interactions and adverse effects similar to warfarin.

Primary Characteristics

Nicoumalone is also known as Acenocoumarol , acenoc(o)umarin.

It is of Semi Synthetic origin and belongs to Coumarin.

It belongs to Epoxide Reductase inhibitor pharmacological group on the basis of mechanism of action and also classified in Anticoagulants pharmacological group.

Molecular Weight: 353.3 · Solubility in Alcohol: 1 in 400 · Non-proprietary name: Nicoumalone.

Molecular structure of Nicoumalone

Pharmacokinetics

Absorption: Nicoumalone has an oral bioavailability is 83% (±7%).

Distribution: Nicoumalone has a volume of distribution is 0.3 l/kg. plasma protein binding is 98 %.

Elimination: it is metabolised via extensive, plasma half-life is 8 hr, renal excretion is 60 %.

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Indications

Contraindications

Nicoumalone is contraindicated in conditions like Haemorrhage, Cerebrovascular disease.

Dosage

Nicoumalone's dosage details are as follows:

DoseSingle DoseFrequencyRouteInstructions
Adult Dosage
4 – 12 mgEvery 24hPOInitial, Reduce dose on second day
1 – 8 mgPOMaintenance, As required
Paediatric Dosage (20kg)
0 – 0Not recommended for this age group
Neonatal Dosage (3kg)
0 – 0Not recommended in this age group

Drug Interactions

Unknown10 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Nicoumalone in overdosage may give rise to further complications which include Skin necrosis .

Nicoumalone produces potentially life-threatening effects which include Hemorrhage , GI bleeding, Hematuria, Bruising , Hemorrhage. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Nicoumalone are Bleeding .

Warnings / Precautions

Nicournalone should be used with caution in patients with ulcers, unusual menstrual periods, diabetes, liver or kidney disease, high blood pressure, arthritis, thyroid problems, all recent infections, if have had recent surgery or of drug and food allergies. If patient have an illness that causes vomiting, diarrhea or fever for more than a few days, contact the doctor as these problems can change the effect of drug. Limit consumption of alcoholic beverages. Avoid sudden changes in dietary habits, Avoid ingesting unusual increases or decreases of foods high in Vitamin K (e.g.liver, cauliflower, cabbage, spinach and other green leafy vegetables, green tea, certain vegetables, cheeses and certain vitamin supplements). It is best to avoid strictly vegetarian diets that consist of foods high in vitamin K. Be extra careful to avoid injuries, because this medication can cause heavy bleeding. Be careful while brushing teethes or use an electric razor. It should not be used during pregnancy. It should be used with caution during lactation.

Interference in Pathology

Nicoumalone may interfere in the diagnosis of Urinanalysis , Increased values of hepatic enzymes.

Available Brands

None recorded.

Storage Conditions

Nicoumalone should be stored Tab.

Drug Classification

  1. 1.10.2Anticoagulants/Platelet deaggregators