Methyprylone

Drug #473

Chemically Methyprylone is 3, 3-diethyl-5-methyl-2, 4-piperidinedione. Methyprylone is oral hypnotic and used in the management of insomnia of varied etiology.

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Primary Characteristics

It is of Synthetic origin and belongs to Piperidine.

It belongs to Hypnotic pharmacological group on the basis of mechanism of action.

Molecular Weight: 183.2 · pK_a: 12.0 · Solubility in Water: 1 in 14 · Solubility in Alcohol: 1 in 0.7 · Non-proprietary name: Methyprylone.

Pharmacokinetics

Distribution: Methyprylone has a volume of distribution is 0.97 l/kg. plasma protein binding is 60 %.

Elimination: it is metabolised via extensive by Liver, plasma half-life is 6-16 hr, renal excretion is 60 %.

Indications

Methyprylone is primarily indicated in conditions like Insomnia.

Contraindications

Methyprylone is contraindicated in conditions like Alcohol dependence, Depression, Porphyria, Sleep apnea syndrome.

Dosage

Methyprylone's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
1.309 mg/kg	1.309 mg/kg	Every 8h	PO	-
Paediatric Dosage (20kg)
0 – 0	—	—		Not recommended for this age group
Neonatal Dosage (3kg)
0 – 0	—	—		Not recommended in this age group

Drug Interactions

Unknown1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Methyprylone in overdosage may give rise to further complications which include Polyuria , Anxiety , Hallucinations , Seizures , Hyperreflexia , Dependence .

Methyprylone produces potentially life-threatening effects which include Pulmonary edema , Coma, Respiratory depression, Hypotension. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Methyprylone are Coma, Hyperthermia, Respiratory depression, Hypothermia, Pupillary changes, Dysarthria , Nystagmus.

Methyprylone is known to cause more or less tolerable side effects which are usually transient. These include CNS disturbances , GI disturbance.

Warnings / Precautions

Patient should observe caution while driving or performing other task requiring alertness because it may produce dizziness. Total daily intake should not exceed to 400 mg. Methyprylone should be used with caution in patients with kidney and liver disease. Perform periodic blood counts if use over prolonged period. Patients should be warned against the concomitant use of methyprylone and alcohol or other CNS depressants. Habituation and physical dependence have been reported to occur when excessive doses are taken over an extended period of time.

Interference in Pathology

Methyprylone may interfere in the diagnosis of Holotorff Koch Modification of the Zimmerman Test for determinatin of 17-Ketosteroids .

Available Brands

None recorded.

Storage Conditions

Methyprylone should be stored .

Drug Classification

1.24.3 — Drugs used in anxiety and sleep disorders