Methacycline (HCl)
Also known as: Metacycline
Methacycline (HCl) is a tetracycline antibiotic. Tetracyclines are derivative of polycyclic naphthacenecarboxamide. Tetracyclines are broad spectrum antibiotic. They are bacteriostatic and effective against many gram positive and gram negative bacteria. Antibiotics require constant drug level in body for therapeutic effect. This is achieve by taking the drug at regular intervel of time throughout the day and night as prescribed. Methacycline (HCl) is important to take the drug for the full time period as prescribed. If you discontinue the drug, it may result in ineffective treatment. The antimicrobial agents develops during the last 60 years are among the most dramatic examples of the advances of science. The remarkably powerful and specific activity of antimicrobial drug is due to the their selectivity for highly specific targets that are either unique to micro-organism or much more important in them than in humans.
Primary Characteristics
Methacycline (HCl) is also known as Metacycline.
It is of Semi Synthetic origin and belongs to Tetracycline.
It belongs to Antibacterial (Proetin synthesis inhibitor) pharmacological group on the basis of mechanism of action and also classified in Antibiotic, Tetracycline Derivative pharmacological group.
Molecular Weight: 478.9 · pKa: 3.1, 7.6, 9.5 · Solubility in Water: 1 in 100 · Solubility in Alcohol: 1 in 300 · Non-proprietary name: Methacycline (HCl) · pH: 2.
Pharmacokinetics
Absorption: Methacycline (HCl) has an oral bioavailability is 60%.
Distribution: Methacycline (HCl) has a volume of distribution is 0.97 l/kg. plasma protein binding is 80-95 %.
Elimination: plasma half-life is 14-15 hr, renal excretion is 30 %.
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Indications
Methacycline (HCl) is primarily indicated in conditions like Bacterial infections, Gonorrhoea, Pneumonia, Syphilis.
Contraindications
Methacycline (HCl) is contraindicated in conditions like Hypersensitivity to any component of product.
Dosage
Methacycline (HCl)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 600 mg | 600 mg | Every 12h | PO | In 2 divided doses 1 or 2 he after meals. |
| Paediatric Dosage (20kg) | ||||
| 0.18 mg/kg | 0.18 mg/kg | Every 12h | Oral | Dose for over 8 Yrs paeds |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not use in this age group | |
Drug Interactions
None recorded.
Side Effects
Methacycline (HCl) in overdosage may give rise to further complications which include Azotemia, Acidosis , Hyperphosphatemia.
Methacycline (HCl) produces potentially life-threatening effects which include Anaphylaxis . Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Methacycline (HCl) are Vomiting, Diarrhea.
Methacycline (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Anorexia , Benign intracranial hypertension, Dysphagia, Enterocolitis , Erythematous rash, Exfoliative dermatitis, Glossitis, Maculopapular rash, Nausea, Photosensitivity reactions, Superinfection .
Warnings / Precautions
Interference in Pathology
Methacycline (HCl) may interfere in the diagnosis of Flase +ve Flourescence in the Hingerty Method for measuring Catecholamines. , Flase +ve Urea Level in pre-existing renal impairment .
Available Brands
None recorded.
Storage Conditions
Drug Classification
- 1.6.2.2.3 — Tetracyclines