Metaraminol

Also known as: Hydroxynorephedrine Bitartrate, Metaradrine Bitartrate

Drug #457

Metaraminol (Bitartrate) is a mixed acting sympathomimetic agent that is similar to norepinephrine in its actions, although Metaraminol (Bitartrate) is less potent. Metaraminol (Bitartrate) is administered intramuscularly or intravenously.

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Primary Characteristics

Metaraminol is also known as Hydroxynorephedrine Bitartrate, Metaradrine Bitartrate, Metaraminol (Bitartrate).

It belongs to Amine.

It belongs to Alpha adrenergic agonist pharmacological group on the basis of mechanism of action and also classified in Vasoconstrictor pharmacological group. It is also classified under Drugs used in Shock .

Molecular Weight: 317.2 · pK_a: 8.79 · Solubility in Water: freely Soluble · Solubility in Alcohol: Sparingly soluble · Non-proprietary name: Metaraminol · pH: 3.8 · Isotonic value: 5.17.

Pharmacokinetics

Distribution: Metaraminol has a plasma protein binding is ~40%.

Elimination: it is metabolised via hepatic.

Indications

Metaraminol is primarily indicated in conditions like Acid-related dyspepsia, Acute hypotension, Hypotension, Shock.

Metaraminol is also indicated for secondary conditions like Brain tumors, Priapism, Trauma.

Contraindications

Metaraminol is contraindicated in conditions like Hypersensitivity.

Dosage

Metaraminol's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
6 mg	6 mg	—	IM	As Required
2.75 mg	2.75 mg	—	IV	initial
57.5 mg	57.5 mg	—	IV	Maintenace
0.085 mg/kg	0.085 mg/kg	—	SC	As Required
Paediatric Dosage (20kg)
0 – 0	—	—		Not recommended for this age group
Neonatal Dosage (3kg)
0 – 0	—	—		Not recommended in this age group

Drug Interactions

Unknown3 interactions

Major3 interactions

Moderate3 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Metaraminol in overdosage may give rise to further complications which include Abscess formation , Tissue necrosis , Sloughing , Convulsions , Tachycardia , Confusion , Insomnia , Tremors .

Metaraminol produces potentially life-threatening effects which include Cardiac arrhythmia, Sinus tachycardia, Ventricular tachycardia. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Metaraminol are Pulmonary edema , Hypertension.

Metaraminol is known to cause more or less tolerable side effects which are usually transient. These include Anxiety, Dizziness, Dyspnea, Headache, Nausea and vomiting.

Warnings / Precautions

Metaraminol should be used with caution in heart disease, thyroid disease, hypertension & diabetes. It should be used in large vein to avoid necrosis & sloughing of surrounding tissues. Cautions should be taken during pregnancy.

Available Brands

None recorded.

Storage Conditions

Metaraminol should be stored Inj.

Drug Classification

1.12.8 — Other cardiovascular preparations
2.21.4.3 — Sympathomimetics