Levorphanol

Also known as: Phenonthrence

Drug #417

Levorphanol (Tartrate) is a narcotic analgesic similar to morphine, but more reliable when administered orally. Useful in the treatment of severe chronic pain in terminal disease.

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Primary Characteristics

Levorphanol is also known as Phenonthrence.

It is of Synthetic origin and belongs to Opioid.

It belongs to OPIATE agonist pharmacological group on the basis of mechanism of action and also classified in Analgesic pharmacological group.

Molecular Weight: 443.5 · pK_a: 8.2 · Solubility in Water: 1 in 40 · Solubility in Alcohol: 1 in 110 · Non-proprietary name: Levorphanol (Tartrate).

Pharmacokinetics

Absorption: Levorphanol has an oral bioavailability is 60.5% (±9.5%), pre-systemic (first-pass) metabolism accounts for 50%.

Distribution: Levorphanol has a volume of distribution is 10 - 13 l/kg. plasma protein binding is 40 %.

Elimination: it is metabolised via Hepatic, plasma half-life is 11 hr.

Indications

Levorphanol is primarily indicated in conditions like Adjunct to anesthesia, As a premedicant, Pain, Surgical anaesthesia.

Contraindications

Levorphanol is contraindicated in conditions like Depression, Heart failure, Hypovolaemia, Respiratory disease, Hypersensitivity.

Dosage

Levorphanol's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
0.024 mg/kg	0.024 mg/kg	—	IM	As Required
0.024 mg/kg	0.024 mg/kg	—	IV	As Required
2.5 mg	2.5 mg	Every 8h	PO	Initial or a dose may be increased to 12mg
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown3 interactions

1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Levorphanol in overdosage may give rise to further complications which include Hypotension , Hypotension , Urinary retention, Rhabdomyolysis , Dizziness , Respiratory depression , Cough , Urinary retention.

The signs and symptoms that are produced after acute overdosage of Levorphanol are Nausea, Cardiac arrhythmias, Convulsions , Coma, Urinary retention, Emesis, Hyperventilation, Bradypnea, Airway obstruction, Urticaria.

Levorphanol is known to cause more or less tolerable side effects which are usually transient. These include Circulatory failure, Constipation , Faintness , Headache, Hypotension , Nausea and vomiting, Rashes , Vomiting .

Warnings / Precautions

Levorphanol should be used with caution in patients with central nervous system (CNS) depression, convulsive disorder, ulcerative colitis, fever, recent gastrointestinal (GI) surgery, bradyarrhythmias, supraventricular tachycardia, pulmonary diseases. Patients should exercise caution while driving or performing tasks requiring alertness because it may produce drowsiness. Cautions should be taken in allergic patients. Alcohol should be avoided while using levorphanol.

Available Brands

None recorded.

Storage Conditions

Levorphanol should be stored Tab, Inj.

Drug Classification

1.2.2 — Opioid analgesics