Ketoprofen
Ketoprofen is NSAID (non-steroidal anti-inflammatory drug). Ketoprofen is a propionic acid derivative and widely used in the treatment of pateints with rheumatic diseases. It reduces fever, inflammation or swelling and relieves pain. Ketoprofen is used to treat pain, swelling and stiffness associated with arthritis. Ketoprofen is also used to treat headaches, muscle aches and dental pain. Ketoprofen is available for oral, rectal, parentral and topical administration. Chemically Ketoprofen is (R, S)-2-(3-benzoylpheny) propionicacid. It inhibits cyclooxygenase actvity with reduction in the tissue production of prostaglandins such as PGE-2 and PGF-2a
Primary Characteristics
It is of Synthetic origin and belongs to Propionic Acid.
It belongs to Cyclo-oxygenase inhibitor pharmacological group on the basis of mechanism of action. It is also classified under Analgesics and Anti-inflammatory Agents .
Molecular Weight: 254.3 · pKa: 4.55 · Solubility in Water: Insoluble · Solubility in Alcohol: Freely soluble · Non-proprietary name: Ketoprofen.
Pharmacokinetics
Absorption: Ketoprofen has an oral bioavailability is 94% (±4%), pre-systemic (first-pass) metabolism accounts for 45.5% (±4.5%).
Distribution: Ketoprofen has a volume of distribution is 0.11 l/kg. plasma protein binding is 95%.
Elimination: it is metabolised via extensively by liver, plasma half-life is 1.5-4 hr, renal excretion is 1% (unchanged).
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Indications
Ketoprofen is primarily indicated in conditions like Ankylosing spondylitis, Bursitis, Gastro-oesophageal reflux disease, Gout, Lumbago, Management of cushing`s syndrome, Musculoskeletal disorders, Osteoarthritis, Pain, Rheumatic diseases, Rheumatoid arthritis, Synovitis, Tendinitis, Tenosynovitis.
Ketoprofen is also indicated for secondary conditions like Dental pain, Dysmenorrhoea, Fever, fever, Infections, Migraine, Orthopedic manipulations.
Contraindications
Ketoprofen is contraindicated in conditions like Peptic ulcer, Bronchospasm, Rhinitis, Renal insufficiency.
Dosage
Ketoprofen's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 150 mg | 150 mg | — | In 2 to 4 divided dosed for rheumatic disorders. | |
| 100 mg | 100 mg | Every 24h | Intra Rectal | At bed time , Total dose should not exceed 200mg. |
| 50 – 75 mg | — | Every 12h | PO | 50mg 3 times 75 mg 4 times |
| Paediatric Dosage (20kg) | ||||
| 0 – 0 | — | — | Not recommended for this age group | |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Ketoprofen in overdosage may give rise to further complications which include Reduced GFR (glomerular filtration rate), Acute interstitial nephritis , Platelet dysfunction .
Ketoprofen produces potentially life-threatening effects which include Gastrointestinal hemorrhage. Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Ketoprofen are Hypotension, Vomiting, Bronchospasm, Drowsiness, Drowsiness, Abdominal pain, GI hemorrhage.
Ketoprofen is known to cause more or less tolerable side effects which are usually transient. These include Bullous rash, Constipation , Diarrhea, Dyspepsia , Gastric pain, GI upset, Nausea, Photosensitivity, Skin rash, Vertigo, Vomiting .
Warnings / Precautions
Interference in Pathology
Ketoprofen may interfere in the diagnosis of Liver Function Test (LFT) , Complete blood cell count.
Available Brands
Storage Conditions
Drug Classification
- 1.2.1.3 — Non steroidal anti-inflammatory drugs (NSAIDs)
- 2.2.5 — Antirheumatics, topical