Hyoscine (Butylbromide) - Drug Monograph

Primary Characteristics

Hyoscine (Butylbromide) is also known as Butylscopalamine bromide, Hyoscine .

It is of Natural origin and belongs to Tropane Alkaloid.

It belongs to Cholinergic muscarinic antagonist pharmacological group on the basis of mechanism of action. It is also classified under Gastrointestinal Anticholinergics/Antispasmodics .

Molecular Weight: 440.4 · pK_a: 8.1 · Solubility in Water: 1 in 1 · Solubility in Alcohol: 1 in 50 · Non-proprietary name: Hyoscine (Butylbromide).

Molecular structure of Hyoscine (Butylbromide)

Pharmacokinetics

Absorption: Hyoscine (Butylbromide) has an oral bioavailability is 9% (±1%).

Distribution: Hyoscine (Butylbromide) has a plasma protein binding is 10%.

Elimination: it is metabolised via hepatic, plasma half-life is 8 hr, renal excretion is >2%.

Indications

Hyoscine (Butylbromide) is primarily indicated in conditions like Acute spasm and spasm in diagnostic procedures, Aspiration prophylaxis, Bradycardia, Cycloplegia induction, Drying secretions, amnesia, Iritis, Irritable bowel syndrome, Motion sickness, Mydriasis induction, Reduction of excessive respiratory secretions (death rattle) in palliative care, Smooth muscle spasm, Symptomatic relief of GI-disorders, The pain of bowel colic in palliative care, Uveitis.

Hyoscine (Butylbromide) is also indicated for secondary conditions like Premedication in anaesthesia.

Contraindications

Hyoscine (Butylbromide) is contraindicated in conditions like Glucoma, Prostatic hypertrophy, Paralytic ileus.

Dosage

Hyoscine (Butylbromide)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
20 mg	20 mg	Every 4h	PO	In Anti spasmodic condition
20 mg	20 mg	—	Slow IV	20 mg repeated after 30 min 100 mg daily
Paediatric Dosage (20kg)
15 ug/kg	15 ug/kg	—	Intra Muscular	Single Dose
15 ug/kg	15 ug/kg	—	Subcutaneous	Single Dose
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown3 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Hyoscine (Butylbromide) produces potentially life-threatening effects which include Seizures , Transient arrhythmias, Hallucination. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Hyoscine (Butylbromide) are Coma, Blurred vision, Hallucinations , Dry flushed skin, Delirium, Ataxia, Restlessness , Rapid & irregular pulse, Decreased salivary secretions, Increased heart rate, Loss of accomodation, Flushed skin, scarlet, weak pulse, Excitement.

Hyoscine (Butylbromide) is known to cause more or less tolerable side effects which are usually transient. These include Blurring of vision, Constipation , Cycloplegia, Delirium , Dizziness, Drowsiness, Dry mouth, Fatigue, Headache, Loss of accomodation, Mydriasis, Nausea and vomiting, Palpitation, Restlessness, Swallowing difficulties, Tachycardia, Thirst, Transient bradycardia, Urinary RetentionX.

Warnings / Precautions

Hyoscine butylbromide should be used with caution in patients with any allergy (especially drug allergies), glaucoma (narrow-angle), liver or kidney disease or severe narrowing of the stomach, intestines or bladder. Limit alcohol intake, as it may worsen certain side effects of this medication. Since this drug may cause dizziness, drowsiness and blurred vision, so use with caution while driving or performing tasks requiring alertness. Protect eyes from bright light and wear UVA/UVB sunglasses while eyes are dilated. It should be used only when clearly needed during pregnancy. The elderly and children are particularly sensitive to the side effects of this drug, therefore caution is advised with use of this drug. Should be use with caution in Gerd ulcerative clitis close angleglaucoma to pyrexia.

Available Brands

Click on a strength to view available brands.

Single Ingredient

Inj

20 mg/ml 4 mg/ml 5 mg/ml

Syrup

5 mg/5ml

Tabs

10 mg

Multi-Ingredient Combinations

Inj

10 mg/ml 4 mg/ml

Tabs

10 mg

Storage Conditions

Hyoscine (Butylbromide) should be stored Inj. Tab.

Drug Classification

1.17.5 — Antispasmodics

Manufacturers

Manufacturers of Hyoscine (Butylbromide) in Pakistan: