Hydroflumethiazide

Also known as: Dihydroflumethiazide, Hydroflumetiazid

Drug #367

Hydroflumethiazide is a diuretic. It increases urination. Hydroflumethiazide is used in hypertention to lower the high blood pressure and also to treat fluid overload.

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Primary Characteristics

Hydroflumethiazide is also known as Dihydroflumethiazide, Hydroflumetiazid.

It is of Synthetic origin and belongs to Sulphonamide.

It belongs to NaCl cotransport inhibitor pharmacological group on the basis of mechanism of action and also classified in Diuretic Thiazide pharmacological group.

Molecular Weight: 331.3 · pK_a: 8.5, 10.0 · Solubility in Water: insoluble · Solubility in Alcohol: soluble · Non-proprietary name: Hydroflumethiazide.

Molecular structure of Hydroflumethiazide

Pharmacokinetics

Distribution: Hydroflumethiazide has a volume of distribution is 6.4 l/kg. plasma protein binding is 75%.

Elimination: plasma half-life is 7 hr, renal excretion is >60%.

Indications

Hydroflumethiazide is primarily indicated in conditions like Disorders of calcium balance, Edema, Heart failure, Hypertension, Oedema.

Hydroflumethiazide is also indicated for secondary conditions like Diabetes insipidus.

Contraindications

Hydroflumethiazide is contraindicated in conditions like Diabetes mellitus, Hypokalaemia.

Dosage

Hydroflumethiazide's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
1.607 mg/kg	1.607 mg/kg	Every 24h	PO	Maintenance, As Required
12.5 mg	12.5 mg	—	PO	Initially for Once. For Hypertension
37.5 mg	37.5 mg	Every 24h	PO	For oedema.
62.5 mg	62.5 mg	Every 24h	PO	Initially given & reduce for maintanance.
75 mg	75 mg	Every 24h	PO	On Alternate days.
Paediatric Dosage (20kg)
1 mg/kg	1 mg/kg	Every 24h	Oral	-
Neonatal Dosage (3kg)
1 mg/kg	1 mg/kg	Every 24h	Oral	-

Drug Interactions

Unknown7 interactions

1 interaction

Moderate1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Hydroflumethiazide in overdosage may give rise to further complications which include Acute interstitial pulmonary edema , Atherosclerosis , Cholestatic jaundice , Necrotising vasculitis , Pancreatitis , Photosensitivity , Skin rashes , Thrombocytopenia .

Hydroflumethiazide produces potentially life-threatening effects which include Hyponatremia, Hypokalemia, Cardiac arrhythmias, Abnormal lipid profile, Hypoplastic Anemia . Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Hydroflumethiazide are Hypotension, Volume depletion, Renal failure, Hypokalemia , Hyponatremia.

Hydroflumethiazide is known to cause more or less tolerable side effects which are usually transient. These include Dizziness, Gout, Headache, Impotence, Nausea, Night cramps, Polyuria, Thirst.

Warnings / Precautions

Thiazide diuretics increase sensitivity to sunlight, so avoid prolonged sun exposure, use a sunscreen and wear protective clothing. This medication should be used during pregnancy or lactation only if clearly needed. It should be used with caution in patients with gout or diabetes or any allergies especially to sulfa medications. Avoid any drugs that increase heart rate or cause excitation like decongestants (present in cough or cold products) because it may counter-act the blood pressure medicine.

Interference in Pathology

Hydroflumethiazide may interfere in the diagnosis of False Low values in GLC assay of Urinary oestriol .

Available Brands

None recorded.

Storage Conditions

Hydroflumethiazide should be stored Tab.

Drug Classification

1.16.1 — Thiazide and related diuretics