Alcuronium (Cl)
Also known as: Allnortoxiferin Chloride
Alcuronium (Cl) is a competitive or non-depolarizing neuromuscular blocking agent. Alcuronium (Cl) is a synthetic derivative of the curare alkaloid Toxiferine. Alcuronium (Cl) is used to provide muscle relaxation in general anaesthesia (loss of conciousness) for surgical procedures.it has an intermediate onset and duration of action.
Primary Characteristics
Alcuronium (Cl) is also known as Allnortoxiferin Chloride.
It is of Synthetic origin and belongs to Nortoxiferinium.
It belongs to Cholinergic nicotinic antagonist pharmacological group on the basis of mechanism of action and also classified in Muscle Relaxants pharmacological group.
Molecular Weight: 827.9 · Solubility in Water: 1 in 10 to 1 in 30 · Solubility in Alcohol: 1 in 10 to 1 in 30 · Non-proprietary name: Alcuronium (Cl).
Pharmacokinetics
Distribution: Alcuronium (Cl) has a volume of distribution is 0.41 l/kg. plasma protein binding is 40%.
Elimination: plasma half-life is 3 hr, renal excretion is 80-85%.
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Indications
Alcuronium (Cl) is primarily indicated in conditions like Adjunct to anesthesia, Neuromuscular blockade.
Contraindications
Alcuronium (Cl) is contraindicated in conditions like Hypersensitivity.
Dosage
Alcuronium (Cl)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 0.25 mg/kg | 0.25 mg/kg | — | IV | As Required |
| Paediatric Dosage (20kg) | ||||
| 0.165 mg/Kg | 0.165 mg/Kg | — | Intra Venous | As Required |
| Neonatal Dosage (3kg) | ||||
| 0.165 mg/Kg | 0.165 mg/Kg | — | Intra Venous | As Required |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Alcuronium (Cl) produces potentially life-threatening effects which include Anaphylactoid reactions , Hypotension, Bronchospasm , Cardiac Arrest , Cardiac arrest, Bronchospasm. Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Alcuronium (Cl) are Prolonged respiratory & muscular paralysis.
Alcuronium (Cl) is known to cause more or less tolerable side effects which are usually transient. These include GI symptoms, Increase in heart rate , Skin reactions.
Warnings / Precautions
Available Brands
None recorded.
Storage Conditions
Drug Classification
- 1.20 — Muscle relaxants and cholinesterase inhibitors