Droperidol

Drug #268

Droperidol is a drug of the butyrophenone series. Droperidol is used for its antianxiety, sedative, tranquilizer and antiemetic effects. Droperidol is a component of neuroleptic anesthesia. Droperidol is used in surgical and diagnostic procedures for its calming effect. It decreases anxiety and pain, reduces nausea and vomiting induced by cancer chemotherapy and may be effective during labor and delivery. Droperidol is administered intramuscularly or intravenously.

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Primary Characteristics

Droperidol is also known as Dehydrobenzoeridol.

It is of Synthetic origin and belongs to Butyrophenone.

It belongs to D2 antagonist pharmacological group on the basis of mechanism of action. It is also classified under Psychotherapeutic Drugs .

Molecular Weight: 379.4 · pK_a: 7.6 · Solubility in Water: < 1 in 10000 · Solubility in Alcohol: 1 in 140 · Non-proprietary name: Droperidol.

Pharmacokinetics

Distribution: Droperidol has a volume of distribution is Children:- 0.6L/kg,adult:- 1.5L/kg. plasma protein binding is 85% to 90%.

Elimination: it is metabolised via extensive by liver, plasma half-life is 2.3 hr, renal excretion is 75% <1% as unchanged drug.

Indications

Droperidol is primarily indicated in conditions like Aggression, Anxiety, General anaesthesia, Hyperactivity, Hyperemesis gravidarum, Nausea and vomiting, Regional anaesthesia, Schizophrenia.

Droperidol is also indicated for secondary conditions like Induction, Induction and maintenance of anaesthesia, Sedation, Surgical anaesthesia.

Contraindications

Droperidol is contraindicated in conditions like Parkinson's disease, Comatose states.

Dosage

Droperidol's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
0.143 mg/kg	0.143 mg/kg	—	IV	As Required
0.937 mg	0.937 mg	—	IV	At the end of surgery recommended prophyledic doses of antiemetic for PONV.
60 mg/kg	60 mg/kg	—	IV	At the end of surfery recommended for prophylactic doses of antiemetics for PONV.
Paediatric Dosage (20kg)
0.3 mg/kg	0.3 mg/kg	—	Intra Muscular	Single Dose
50 – 70 mg/kg	—	—	Iv	At the end of surfery recommended for prophylactic doses of antiemetics for PONV.
0.3 mg/kg	0.3 mg/kg	—	Oral	Single Dose
Neonatal Dosage (3kg)
0.3 mg/kg	0.3 mg/kg	—	Intra Muscular	Single Dose
0.3 mg/kg	0.3 mg/kg	—	Oral	Single Dose

Drug Interactions

Unknown9 interactions

5 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Droperidol in overdosage may give rise to further complications which include Tardive dyskinesia , Oculogyric crises , Laryngeal dystonias, Cardiac arrest , Acute dystonia .

Droperidol produces potentially life-threatening effects which include Arrhythmias, Neuroleptic Malignant Syndrome , Neuroleptic malignant syndrome. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Droperidol are Hypotension, Cardiac arrhythmias, Convulsions , Coma, Respiratory depression, Respiratory depression, Sedation , Extrapyramidal effects , Respiratory depression.

Droperidol is known to cause more or less tolerable side effects which are usually transient. These include Akathisia, Alertness impairment, Blood dyscrasias, dizziness, Dystonic reactions, Extrapyramidal effects, Galactorrhea, Gynecomastia, Headache, HyperprolactinemiaX, Hypotension , Oligomenorrhea, Paradoxical effects, Sedation .

Warnings / Precautions

It should be used with caution in elderly and debilitated patients because they are at an increased risk of developing adverse reactions, in patients with cardiac disease, in patients with seizure disorder or who are taking anticonvulsants, in patients with a history of phenothiazine hypersensitivity because of its structural similarities to this class of drugs. It is classified as pregnancy category C drug. It should be used with caution during pregnancy only if the potential benefit outweighs the risk to the fetus. Use with caution in women who are breast feeding. Safety in children under 2 years of age has not been established. It should not be used during procedures designed to accurately ascertain the pulmonary artery pressure because droperidol can decrease pulmonary artery pressure.

Available Brands

None recorded.

Storage Conditions

Droperidol should be stored Inj.

Drug Classification

1.24.1 — Drugs used in psychotic disorders