Eslicarbazepine Acetate

Drug #2334

The chemical name of eslicarbazepine acetate is (S)-10-Acetoxy-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide. eslicarbazepine is a dibenz[b,f]azepine-5 carboxamide. It is indicated for adjunctive therapy in the treatment of partial onset seizures in patient with epilepsy.

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Primary Characteristics

It is of Synthetic origin and belongs to carboxamide derivatives.

Molecular Weight: 296.32 · Solubility in Water: slightly soluble · Non-proprietary name: Eslicarbazepine Acetate.

Molecular structure of Eslicarbazepine Acetate

Pharmacokinetics

Distribution: Eslicarbazepine Acetate has a volume of distribution is 61 L. plasma protein binding is less than 40%.

Elimination: it is metabolised via hepatic, plasma half-life is 13-20hrs, renal excretion is more than 90% by urine.

Indications

Eslicarbazepine Acetate is primarily indicated in conditions like Partial seizures.

Contraindications

None recorded.

Dosage

Eslicarbazepine Acetate's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
0 – 400 mg	—	—	PO	start dose for partial onset of seizure
0 – 800 mg	—	—	PO	after one week for partial onset of seizure
0 – 1200 mg	—	—	PO	A maximum dose of 1200 mg daily should only be initiated after the patient has tolerated 800 mg daily for at least a week for partial onset of seizure
0 – 200 mg	—	—	PO	start dose for Patients with Renal Impairment
400 mg	400 mg	—	PO	after one week, for Patients with Renal Impairment
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

7 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

None recorded.

Warnings / Precautions

Suicidal Behavior and Ideation: Serious Dermatologic Reactions: Drug Reaction with Eosinophilia and Systemic Symptoms: Multiorgan hypersensitivity. Anaphylactic reactions and angioedema. Hyponatremia. Neurological adverse reactions drug induced liver injury.anbormal thyroi function test

Interference in Pathology

Eslicarbazepine Acetate may interfere in the diagnosis of Thyroid Function Test.

Available Brands

None recorded.

Storage Conditions

Eslicarbazepine Acetate should be stored Tablet.

Drug Classification

1.5 — Anticonvulsants and Antiepileptics