ferric Carboxymaltose

Also known as: VIT 45

Drug #2316

Ferric carboxymaltose, an iron replacement product, is an iron carbohydrate complex with the chemical name of polynuclear iron (III) hydroxide 4(R)-(poly-(1?4)-O-?-Dglucopyranosyl)-oxy-2(R),3(S),5(R),6-tetrahydroxy-hexanoate. Ferric carboxymaltose is a iron replacement product indicated for the treatment of iron deficiency anemia in adult patients who have intolerance to oral iron or have had unsatisfactory response to oral iron or those who have non-dialysis dependent chronic kidney disease.

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Primary Characteristics

ferric Carboxymaltose is also known as VIT 45, iron Dextri-maltose.

It is of Synthetic origin.

Solubility in Water: soluble · Non-proprietary name: ferric Carboxymaltose.

Molecular structure of ferric Carboxymaltose

Pharmacokinetics

Distribution: ferric Carboxymaltose has a volume of distribution is 3L.

Elimination: plasma half-life is 7-12hrs, renal excretion is negligible.

Indications

ferric Carboxymaltose is primarily indicated in conditions like Iron deficiency anaemia.

Contraindications

None recorded.

Dosage

ferric Carboxymaltose's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
0 – 1500 mg	—	—	IV	For patients weighing 50kg (110lb) or more: Give Injectafer in two doses separated by at least 7 days
1125 mg	1125 mg	—	IV	For patients weighing less than 50kg (110lb) or more: Give Injectafer in two doses separated by at least 7 days.gve each dose as 15mg/kg body weight.
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

None recorded.

Side Effects

ferric Carboxymaltose in overdosage may give rise to further complications which include Serious Hypersensitivity reactions.

ferric Carboxymaltose produces potentially life-threatening effects which include Anaphylactic reactions. Careful monitoring is needed with proper medical management.

ferric Carboxymaltose is known to cause more or less tolerable side effects which are usually transient. These include Dizziness, Flushing, Hypertension , Hypophosphatemia, Nausea.

Warnings / Precautions

serious hypersensitivity reactions including anaphylactic tyoe reactions.patient may present with shock, clinically significant hypotension, loss of consciousness and/or collapse.Hypertension,

Interference in Pathology

ferric Carboxymaltose may interfere in the diagnosis of serum Iron, Transferrin bound iron.

Available Brands

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Single Ingredient

Inj

50 mg/ml

Storage Conditions

ferric Carboxymaltose should be stored Injection.

Drug Classification

1.10.1 — Antianemia drugs

Manufacturers

Manufacturers of ferric Carboxymaltose in Pakistan: