Tilmanocept

Drug #2308

Tilmanocept is a new chemical entity and a novel radiodiagnostic imaging agent, targeting the radioisotope, technetium-99m to a mannose-binding protein that resides on the surface of dendritic cells and macrophages.it is used for lymphatic mapping with a hand- held gamma counter to assist in the localization of lymph nodes draining a primary tumor site in patients with breast cancer or melanoma. The chemical name of tilmanocept is dextran, 3 [(2-aminoethyl)thio]propyl 17-carboxy-10, 13, 16-tris(carboxymethyl)-8-oxo-4-thia-7, 10, 13, 16-tetraazaheptadec-1-yl 3-[[2-[[1-imino-2-(D mannopyranosylthio)ethyl]amino]thio]propyl ether

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Primary Characteristics

It is of Synthetic origin.

It belongs to Radiopaque Agents pharmacological group on the basis of mechanism of action.

Molecular Weight: 15 · Solubility in Water: very soluble · Solubility in Alcohol: insoluble · Non-proprietary name: Tilmanocept.

Pharmacokinetics

Elimination: plasma half-life is 1.8-3.1hrs.

Indications

Tilmanocept is primarily indicated in conditions like Breast cancer, Melanoma, Squamous cell carcinoma.

Contraindications

None recorded.

Dosage

Tilmanocept's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
18.5 MBq	18.5 MBq	—	SC	as a radioactiviy dos
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

None recorded.

Side Effects

Tilmanocept is known to cause more or less tolerable side effects which are usually transient. These include injection site irritation, injection site pain.

Warnings / Precautions

Hypersensitivity: Ask patients about prior reactions to drugs, especially dextran or modified forms of dextran. Observe for hypersensitivity signs and symptoms Radiation Risks:Any radiation-emitting product may increase the risk for cancer, especially in pediatric patients. Adhere to the dose recommendations and ensure safe handling to minimize the risk for excessive radiation exposure to either patients or health care workers.

Available Brands

None recorded.

Storage Conditions

Tilmanocept should be stored injection (Use within 6 hours of preparation.).

Drug Classification

1.14.2 — Radiocontrast media