liraglutide
Liraglutide was approved by FDA (US) in 2010 as hypoglycemic subcutaneous drug. Liraglutide is a glucagon like peptide 1 (GLP-1) receptor agoinst. Liraglutide increases intracellular Cyclic AMP leading to insulin release in the presence of elevated glucose concentration.Liraglutide also decreases glucagon secretion and delays in gastric emptying time which resluts in lowering of blood glucose. Liraglutide is indicated for type II Diabetes Mellitus patients adjunct to diet and excercise to improve glycemic control
Primary Characteristics
It is of Semi Synthetic origin and belongs to analog of human GLP-1.
It belongs to Hypoglycaemics pharmacological group on the basis of mechanism of action.
Molecular Weight: 3751.2 · Non-proprietary name: liraglutide · pH: 8.15.
Pharmacokinetics
Distribution: liraglutide has a volume of distribution is 0.07 L/kg.
Elimination: it is metabolised via endogenously metabolized to large protien, plasma half-life is 13 hr, renal excretion is 6% in urine 5% in feces.
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Indications
liraglutide is primarily indicated in conditions like Diabetes mellitus type-ii.
Contraindications
liraglutide is contraindicated in conditions like Thyroid cancer.
Dosage
liraglutide's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 1.2 mg/ml | 1.2 mg/ml | Every 1h | SC | initiate at 0.6 mg/ day for 1 week . |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
liraglutide produces potentially life-threatening effects which include Angioedema , Urticaria. Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of liraglutide are Nausea & vomiting.
liraglutide is known to cause more or less tolerable side effects which are usually transient. These include Back pain, Constipation , Diarrhea, Dizziness, Erythema, Headache, Hypertension , Hypoglycemia, influenza, Injection site reactions, Nasopharyngitis, Nausea and vomiting, Rashes , Sinusitis , urinary tract infection.
Warnings / Precautions
Available Brands
None recorded.