Human Regular Insulin

Also known as: Humulin R

Drug #2242

It is short acting human insulin preparation that can be given intravenously if necessary to cover emergencies. It is also refered as soluble insulin or neutral insulin or unmodified insulin. It's onset of action is 30-60 minutes; while duration of action is 4-12 hours. Peak of action occurs in 2-4 hours. It is synthesized in a special non-disease-producing laboratory strain of Escherichia coli bacteria that has been genetically altered to produce human insulin. The time course of action of any insulin may vary considerably in different individuals or at different times in the same individual. As with all insulin preparations, the duration of action of regular insulin is dependent on dose, site of injection, blood supply, temperature, and physical activity.

← Previous drug Next drug →

Primary Characteristics

Human Regular Insulin is also known as Humulin R.

It is of Natural origin and belongs to Polypeptide.

Molecular Weight: 5080 · Solubility in Water: Slight · Solubility in Alcohol: Very low · Non-proprietary name: Human Regular Insulin.

Molecular structure of Human Regular Insulin

Pharmacokinetics

Distribution: Human Regular Insulin has a volume of distribution is 0.15 L/kg. plasma protein binding is 5%.

Elimination: it is metabolised via 50% Liver,30% kidney, plasma half-life is 4-6 min.

Indications

Human Regular Insulin is primarily indicated in conditions like Type I diabetes mellitus, Type II diabetes mellitus.

Contraindications

None recorded.

Dosage

Human Regular Insulin's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
0.55 unit/ml	0.55 unit/ml	—	IV	(Infusion bags)
0.75 unit/kg/ml	0.75 unit/kg/ml	—	SC
Paediatric Dosage (20kg)
1 unit/kg/d	1 unit/kg/d	—
Neonatal Dosage (3kg)
No data.

Drug Interactions

2 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Human Regular Insulin produces potentially life-threatening effects which include Seizures , Loss of conciousness, Death. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Human Regular Insulin are Hypokalemia .

Human Regular Insulin is known to cause more or less tolerable side effects which are usually transient. These include Anxiety, Dizziness, Headache, Palpitation, Rashes , Shortening of breath, Wheezing .

Warnings / Precautions

Any change in insulin should be made cautiously & only under medical seprervision.

Available Brands

Click on a strength to view available brands.

Single Ingredient

Inj

100 IU/ml

Multi-Ingredient Combinations

Inj

30 %

Storage Conditions

Human Regular Insulin should be stored .

Drug Classification

1.18.7.1 — Insulins

Manufacturers

Manufacturers of Human Regular Insulin in Pakistan:

Lilly