Nitazoxanide

Also known as: Nitazoxanidum, NTZ

Drug #2223

Nitazoxanide is antiprotozoal agent. Chemically, nitazoxanide is 2-acetyloxy-N-(5-nitro-2-thiazolyl)benzamide. The molecular formula is C12H9N3O5S.

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Primary Characteristics

Nitazoxanide is also known as Nitazoxanidum, NTZ.

It is of Synthetic origin and belongs to nitrothiazolyl-salicylamide derivative.

It is classified in Antiprotozoal pharmacological group. It is also classified under Antidiarrhoeals .

Molecular Weight: 307.3 · Solubility in Water: insoluble · Solubility in Alcohol: poorly soluble · Non-proprietary name: Nitazoxanide.

Pharmacokinetics

Distribution: Nitazoxanide has a plasma protein binding is 99%.

Elimination: it is metabolised via by hydrolysis to active metabolite tizoxanide, plasma half-life is 1 to 4 hours for tizoxanide, renal excretion is one third in the urine and two third in feces.

Indications

Nitazoxanide is primarily indicated in conditions like Diarrhea caused by Cryptosporidium parvum, Diarrhea caused by Giardia lamblia, HIV infection.

Contraindications

Nitazoxanide is contraindicated in conditions like Hypersensitivity to the drug, Hypersensitivity to any component of product.

Dosage

Nitazoxanide's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
500 mg	500 mg	Every 12h	PO	Take with food for three days.
1000 mg	1000 mg	Every 12h	PO	This dose is for diarrhea in AIDS patients for 14 days or until diarrhea resolves. Take with food.
Paediatric Dosage (20kg)
100 mg	100 mg	Every 12h		For 3 days in those aged 1 to 3 years
200 – 200 mg	—	Every 12h	PO	For 4 to 11 years age. Take with food for three days.
Neonatal Dosage (3kg)
No data.

Drug Interactions

1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Nitazoxanide in overdosage may give rise to further complications which include Allergic reactions .

Nitazoxanide is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Diarrhea, Discoloration of eyes, Discoloration of urine, dizziness, Flatulence, Headache, Nausea, Vomiting .

Warnings / Precautions

Nitazoxanide must be administered with caution to patients with hepatic and bilary diseases, to patients with renal diseases, and to patients with combined renal and hepatic disease. It is not known whether nitazoxanide is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when nitazoxanide is administered to a nursing women.

Available Brands

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Single Ingredient

Susp

100 mg 100 mg/5ml

Tabs

500 mg

Storage Conditions

Nitazoxanide should be stored tablet (Discard unused prepared suspension after 7 days.). Suspension.

Drug Classification

1.6.4.1 — Antiamebic & antigiardiasis drugs
2.17.7.2 — Antidiarrheals

Manufacturers

Manufacturers of Nitazoxanide in Pakistan:

Genix Helix Hilton Macter Neo S.J.& G Sami