Aliskiren
Aliskiren decreases the bodies which narrows the blood vessels and cause hypertension. Aliskeirn is orally active renin inhibitor used in the management of hypertension; it prevents the conversion of angiotensinogen into angiotensin I and therefore inhibits the production of angiotensin II and aldosterone.
Primary Characteristics
Non-proprietary name: Aliskiren.
Pharmacokinetics
Absorption: Aliskiren has an oral bioavailability is 2.5%.
Elimination: plasma half-life is 24-40 hours, renal excretion is 25%.
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Indications
Aliskiren is primarily indicated in conditions like Hypertension.
Contraindications
Aliskiren is contraindicated in conditions like Diabetes insipidus, Diabetes mellitus, Gout.
Dosage
Aliskiren's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 150 mg | 150 mg | Every 24h | PO | This is the Initial Dose. The dosage may be increased to 300 mg daily if blood pressure is not adequately controlled. |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Aliskiren in overdosage may give rise to further complications which include Seizures .
Aliskiren is known to cause more or less tolerable side effects which are usually transient. These include Back pain, Cough , Gout, Headache, Hyperuricemia , Hypotension , Itching, Light headedness, Nausea, Sore throat, Stomach pain, Stuffy nose, Swelling .