Insulin Lispro Protamine

Drug #2189

Insulin lispro protamine suspension (NPL component) is a suspension of crystals produced from combining insulin lispro and protamine sulfate under appropriate conditions for crystal formation. This medication is used to control blood sugar in patients with diabetes mellitus. Controlling high blood sugar helps prevent heart disease, strokes, kidney disease, blindness and circulation problems. It promotes glucose transport, which stimulates carbohydrate metabolism in skeletal and cardiac muscle and adipose tissue. Also promotes phosphorylation of glucose in liver, where it's converted to glycogen. Directly affects fat and protein metabolism, stimulates protein synthesis, inhibits release of free fatty acids, and indirectly decreases phosphate and potassium. It is available in premixed form with insulin lispro in 75/25 and 50/50 ratio.

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Primary Characteristics

Non-proprietary name: Insulin Lispro Protamine.

Molecular structure of Insulin Lispro Protamine

Pharmacokinetics

None recorded.

Indications

Insulin Lispro Protamine is primarily indicated in conditions like Type I diabetes mellitus, Type II diabetes mellitus.

Contraindications

None recorded.

Dosage

Insulin Lispro Protamine's dosage details are as follows:

Dose	Single Dose	Frequency	Route
Adult Dosage
0 – 0 Units	—	—	Sc
0 – 0 Units	—	—	Sc
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

5 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Insulin Lispro Protamine is known to cause more or less tolerable side effects which are usually transient. These include Chills, Fainting, Headache, Hypoglycemia, Tingling of the hand.

Warnings / Precautions

its doses will vary among patients and should be determined by the healthcare provider familiar with the patient’s metabolic needs, eating habits, and other lifestyle variablesThe dose of insulin lispro protamine when available in combination with insulin lispro (75/25 or 50/50 ratio) should be given within 15 minutes before a meal.

Available Brands

Click on a strength to view available brands.

Multi-Ingredient Combinations

Inj

50 %w/v 75 %w/v

Storage Conditions

Insulin Lispro Protamine should be stored .

Drug Classification

1.18.7.1 — Insulins

Manufacturers

Manufacturers of Insulin Lispro Protamine in Pakistan:

Lilly