Quinidine

Drug #2149

Quinidine is an alkaloid, obtained from the bark of cinchona tree, dextrorotatory diastereoisomer of quinine . Quinidine (Bisulphate and Sulphate) is the prototype of class IA antiarrythmic drug, used for the management of atrial flutter and fibrillation.<BR>Quinidine (Sulphate) is a clasantimuscarinic and alpha-blocking properties. It may be effective in suppressing supraventricular and ventricular arrhythmias. It may itself precipitate rhythm disorders, and is best use on spercialist advise.

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Primary Characteristics

Quinidine is also known as Quinidine (Bisulphate and Sulphate), Quinidine (Sulphate).

It is of Natural origin and belongs to Alkaloid.

It belongs to Na-Channel Antiarrhythmic antagonist pharmacological group on the basis of mechanism of action and also classified in Anti arrhythmic agents pharmacological group.

Molecular Weight: 324.43 · pK_a: 4.2,8.8 · Solubility in Water: 1 in 8 · Solubility in Alcohol: 1 in 3 · Non-proprietary name: Quinidine.

Pharmacokinetics

Absorption: Quinidine has an oral bioavailability is 97% (±2%), pre-systemic (first-pass) metabolism accounts for 25% (±5%).

Distribution: Quinidine has a volume of distribution is 2 - 3 L/kg. plasma protein binding is 70 - 95 %.

Elimination: it is metabolised via Hepatic, plasma half-life is 4 - 12 hr, renal excretion is 10% (unchanged).

Indications

Quinidine is primarily indicated in conditions like Atrial fibrillation, Atrial flutter, Extrasystolic atrial tachycardia, Extrasystolic nodal tachycardia, Suppression of supraventricular tachycardias and ventricular arrhythmias, Ventricular tachycardia.

Contraindications

Quinidine is contraindicated in conditions like Heart failure, Myasthenia gravis, Thrombocytopenia, Heart block, Sick sinus syndrome, Atrioventricular block, Hypersensitivity, Torsade de pointes.

Dosage

Quinidine's dosage details are as follows:

Dose	Single Dose	Frequency	Route
Adult Dosage
2.14 mg/kg	2.14 mg/kg	Every 3h	IM
300 mg	300 mg	Every 4.8h	PO
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown55 interactions

20 interactions

Major5 interactions

Moderate5 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Quinidine in overdosage may give rise to further complications which include Hepatitis , Myasthenia gravis , Hemolysis , QT prolongation.

Quinidine produces potentially life-threatening effects which include Cardiac arrhythmia, Heart block, Heart failure. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Quinidine are Quinidine poisoning.

Quinidine is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Anemia, Anorexia , Arthralgia, Atrial fibrillation, Blurred vision, Diarrhea, Dizziness, Esophagitis, Exacerbation of psoriasis, Fever, GI irritation, Headache, Tinnitus, Urticaria, Vomiting .

Warnings / Precautions

Perform periodic blood counts and liver or kidney tests. If there is blood dyscrasias or any sign of liver or kidney disorders then discontinue the use of quinidine. Continuously monitor ECG & determine plasma quinidine level, when large doses are used.

Interference in Pathology

Quinidine may interfere in the diagnosis of Measurement of Urinary 17-OH-Corticosteroids , Fluorometric Estimation of Urinary Catecholamines .

Available Brands

None recorded.

Storage Conditions

Quinidine should be stored Inj. Tab.

Drug Classification

1.12.2 — Antiarrhythmic drugs
2.12.3.5 — Alpha-1 receptor antagonists