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Doxylamine Succinate

Also known as: Doxylamine

Drug #2087

Doxylamine succinate is an antihistamine commonly used as a nighttime sleep aid. This drug is also used to relieve symptoms of hay fever, allergic rhinitis, hives, rash or itching and other allergic reactions.

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Primary Characteristics

Doxylamine Succinate is also known as Doxylamine.

It is of Synthetic origin and belongs to Monoethanolamine derivative.

It belongs to H1-antagonist pharmacological group on the basis of mechanism of action.

Molecular Weight: 388.5 · Solubility in Water: very soluble · Solubility in Alcohol: freely soluble · Non-proprietary name: Doxylamine Succinate.

Molecular structure of Doxylamine Succinate

Pharmacokinetics

Elimination: plasma half-life is 10 hours.

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Indications

Doxylamine Succinate is primarily indicated in conditions like Cold, Cough, Hypersensitivity reactions, Skin diseases.

Doxylamine Succinate is also indicated for secondary conditions like Insomnia, Pruritus.

Contraindications

Doxylamine Succinate is contraindicated in conditions like Porphyria, Hypersensitivity.

Dosage

Doxylamine Succinate's dosage details are as follows:

DoseSingle DoseFrequencyRouteInstructions
Adult Dosage
25 mg25 mg—To a maximum of 150 gm daily.
12.5 – 25 mg—Every 6horal
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Doxylamine Succinate in overdosage may give rise to further complications which include Convulsions , CNS depression, Blurred vision , Ventricular arrhythmia, Psychomotor impairment.

The signs and symptoms that are produced after acute overdosage of Doxylamine Succinate are Tachycardia , Seizures, Ataxia, Tremor, Excitation , Psychosis .

Doxylamine Succinate is known to cause more or less tolerable side effects which are usually transient. These include Drowsiness, Headache, Incoordination , Lassitude , Nausea and vomiting.

Warnings / Precautions

Doxylamine succinate should be used with caution in prostatic hypertrophy, urinary retension, glaucoma and pyloro-duodenal obstruction. It should be used with care in hepatic disease and dose reduction may be necessary in renal impairment. Caution may be required in epilepsy. Children and elderly are more susceptible to side effects.

Available Brands

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Multi-Ingredient Combinations

Tabs
10 mg

Storage Conditions

Doxylamine Succinate should be stored .

Drug Classification

  1. 1.3 — Anti-allergics (Antihistamines) and drugs used in anaphylaxis
  2. 2.25.2.1 — Cold preparations

Manufacturers

Manufacturers of Doxylamine Succinate in Pakistan:

EfrozeHiranisICIRGSami