Phenprocoumon

Drug #2056

Phenprocoumon is an anticogulant functioning as Vit K antagonist.It is derivative of Coumarin.

Primary Characteristics

Molecular Weight: 280.32 · Solubility in Water: 12.9mg/l · Non-proprietary name: Phenprocoumon.

Pharmacokinetics

Distribution: Phenprocoumon has a plasma protein binding is 99%.

Elimination: it is metabolised via hepatic,metabolise to inactive metabolites., plasma half-life is 5-6days.

Indications

Phenprocoumon is primarily indicated in conditions like Prophylaxis of recurrent haemorrhage, Thrombo-embolic complications, Venous thromboembolic disease.

Phenprocoumon is also indicated for secondary conditions like Ischemic stroke prophylaxis.

Contraindications

Phenprocoumon is contraindicated in conditions like Blood dyscrasias, Renal impairment, Pregnancy.

Dosage

None recorded.

Drug Interactions

3 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Phenprocoumon in overdosage may give rise to further complications which include Hemorrhage, Skin necrosis , Hematoma.

The signs and symptoms that are produced after acute overdosage of Phenprocoumon are Jaundice , Melena, Hematuria, Bleeding problems, Pancreatitis.

Phenprocoumon is known to cause more or less tolerable side effects which are usually transient. These include Alopecia, Diarrhea, Nausea and vomiting.

Warnings / Precautions

Phenprocoumon should not be given to patients who are hemmorhagic. Dose alteration should be guided by regular monitoring of oral anticogulant therapy.

Available Brands

None recorded.

Drug Classification

1.10.2 — Anticoagulants/Platelet deaggregators