Polyestradiole Phosphate
Polyestradiol phosphate is a polymer of estradiole which has prolong duration of action and is used in treatment of metastatic prostatic carcinoma.
Primary Characteristics
It belongs to ester.
Molecular Weight: 370.38 · Solubility in Water: soluble · Non-proprietary name: Polyestradiole phosphate.
Pharmacokinetics
Distribution: Polyestradiole Phosphate has a plasma protein binding is extensive.
Elimination: it is metabolised via hepatic.
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Indications
Polyestradiole Phosphate is primarily indicated in conditions like Metastatic carcinoma.
Contraindications
None recorded.
Dosage
Polyestradiole Phosphate's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 120 mg | 120 mg | — | IM | Dose should be decreased upto 40-80mg and should be given every 4 weeks by maintainance. |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
None recorded.
Side Effects
Polyestradiole Phosphate in overdosage may give rise to further complications which include Cholestatic jaundice , Impotence , Gynacomastia , Venous thrombosis .
The signs and symptoms that are produced after acute overdosage of Polyestradiole Phosphate are Bone pain, Hypercalcemia.
Polyestradiole Phosphate is known to cause more or less tolerable side effects which are usually transient. These include Fluid retention, Nausea, Skin reactions.
Warnings / Precautions
Available Brands
None recorded.
Drug Classification
- 1.8.2 — Cytotoxic (anti-neoplastic) drugs