Phenacemide
Phenacemide is an acetyl urea antiepileptic i-e straight chain analogue of a hydantoin.
Primary Characteristics
Molecular Weight: 178.2 · Solubility in Water: 10.2g/l · Non-proprietary name: Pheniramine (Maleate).
Pharmacokinetics
Elimination: it is metabolised via hepatic by microsomal enzymes, plasma half-life is IV:8-17hrs, PO:16-19hrs, renal excretion is IV:68- 94%, PO:70-83%.
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Indications
Contraindications
Phenacemide is contraindicated in conditions like Blood dyscrasias, Hepatic impairment.
Dosage
Phenacemide's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 500 mg | 500 mg | — | oral | |
| Paediatric Dosage (20kg) | ||||
| 0 – 0 | — | — | ||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
None recorded.
Side Effects
Phenacemide in overdosage may give rise to further complications which include Liver damage , Personality disturbances , Aplastic anemia , Aplastic anemia , Psychosis .
The signs and symptoms that are produced after acute overdosage of Phenacemide are nervousness, Shortness of breadth.
Phenacemide is known to cause more or less tolerable side effects which are usually transient. These include Flu like syndrome, Headache, Nausea and vomiting, Swelling of face, Weight gain.
Warnings / Precautions
Available Brands
None recorded.
Storage Conditions
Drug Classification
- 1.5 — Anticonvulsants and Antiepileptics