Cyclopenthiazide

Drug #204

Cyclopenthiazide is a thiazide diuretic. It increases urination. Cyclopenthiazide is used in hypertention to lower the high blood pressure and also used to treat fluid overload.

← Previous drug Next drug →

Primary Characteristics

It is of Synthetic origin and belongs to Benzothiadiazine.

It belongs to NaCl cotransport inhibitor pharmacological group on the basis of mechanism of action and also classified in Diuretic Thiazide pharmacological group.

Molecular Weight: 379.9 · Solubility in Water: negligible · Solubility in Alcohol: 1 in 12 · Non-proprietary name: Cyclopenthiazide.

Pharmacokinetics

Absorption: Cyclopenthiazide has an pre-systemic (first-pass) metabolism accounts for 0.5% (±0.5%).

Elimination: renal excretion is entire.

Indications

Cyclopenthiazide is primarily indicated in conditions like Diabetes insipidus, Edema, Heart failure, Hypercalciuric nephrolithiasis, Hypertension, Oedema.

Contraindications

Cyclopenthiazide is contraindicated in conditions like Gout, Maturity onset diabetes.

Dosage

Cyclopenthiazide's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
0.009 mg/kg	0.009 mg/kg	Every 24h	PO	-
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown2 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Cyclopenthiazide in overdosage may give rise to further complications which include Cholestatic jaundice , Impotence , Loss of libido .

Cyclopenthiazide produces potentially life-threatening effects which include Blood dyscrasias, Hyponatremia, Hypokalemia, Stevens Johnson syndrome, Pancreatitis , Anaphylaxis , Necrotizing vasculitis, Vasculitis . Careful monitoring is needed with proper medical management.

Cyclopenthiazide is known to cause more or less tolerable side effects which are usually transient. These include Glucose intolerance, Reduced uric acid urinary excretion, Volume depletion.

Warnings / Precautions

It should be used with caution in patients with a history of hypersensitivity thiazide or related diuretics or sulfonamide and in patients with hepatic or hepatic disease.

Interference in Pathology

Cyclopenthiazide may interfere in the diagnosis of Benedicts Test for Urinary Reducing Substance.

Available Brands

Click on a strength to view available brands.

Single Ingredient

Eye Drops

1 %w/v

Storage Conditions

Cyclopenthiazide should be stored Tab.

Drug Classification

1.16.1 — Thiazide and related diuretics

Manufacturers

Manufacturers of Cyclopenthiazide in Pakistan:

Nimrall