Oxyphenbutazone

Drug #2027

Oxyphenbutazone, a metabolite of phenylbutazone, is an NSAID. It has been applied topically to the eye as an anti-inflammatory ointment in conditions such as episcleritis. Oxyphenbutazone was used systemically in disorders such as ankylosing spondylitis, osteoarthritis, and rheumatoid arthritis but such use is no longer considered justified owing to the risk of severe haematological adverse effects.

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Primary Characteristics

Molecular Weight: 401.4 · Non-proprietary name: Oxyphenisatin acetate.

Pharmacokinetics

None recorded.

Indications

Oxyphenbutazone is primarily indicated in conditions like Fever, Gout, Osteoarthritis, Pain, Rheumatoid arthritis.

Contraindications

Oxyphenbutazone is contraindicated in conditions like Peptic ulcer, Blood dyscrasias, Congestive heart failure, Hepatitis.

Dosage

Oxyphenbutazone's dosage details are as follows:

Dose	Single Dose	Frequency	Route
Adult Dosage
3.25 mg/kg	3.25 mg/kg	—	IV
6.5 mg/kg/day	6.5 mg/kg/day	—	PO
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

2 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Oxyphenbutazone in overdosage may give rise to further complications which include Allergic reactions , Abdominal pain, Blurred vision .

Oxyphenbutazone is known to cause more or less tolerable side effects which are usually transient. These include Bruising, Diarrhea, Drowsiness, Headache, Heart burn, Irritability, Loss of appetite, Weakness, Weight loss.

Warnings / Precautions

Oxyphenbutazone should be used with caution in patients with incipient cardiac failure, blood dyscrasias, pancreatitis, kidney or liver diseases, gastrointestinal (GI) inflammation.patients should observe caution while driving or performing other tasks requiring alertness, because it may cause drowsiness. It should not be given intramuscularly or injected in any place other than a vein, as it can cause tissue damage. Tissue damage and edema may also occur if the drug is injected repetitively into the same vein.

Available Brands

None recorded.

Storage Conditions

Oxyphenbutazone should be stored Tablets. Parentrals.

Drug Classification

1.2.1.3 — Non steroidal anti-inflammatory drugs (NSAIDs)