Ornidazole

Also known as: Ornidazole is a derivative of 5-nitroimidazole

Drug #2018

Ornidazole is a nitroimidazole antiprotozoal agent used in ameba and trichomonas infections. It is partially plasma-bound and also has radiation-sensitizing action.

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Primary Characteristics

Ornidazole is also known as Ornidazole is a derivative of 5-nitroimidazole.

It belongs to Nitroimidazole.

Molecular Weight: 219.6 · Non-proprietary name: Ornidazole.

Pharmacokinetics

Distribution: Ornidazole has a plasma protein binding is <15%.

Elimination: it is metabolised via Hepatic, plasma half-life is 12-14 hrs.

Indications

Ornidazole is primarily indicated in conditions like Amebiasis, Amoebic dysentry, Bacterial vaginosis, Giardiasis, Trichomoniasis.

Contraindications

Ornidazole is contraindicated in conditions like Hypersensitivity to the drug.

Dosage

Ornidazole's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
1 g	1 g	—	I/V Infusion	30 min before surgery
1.5 gm	1.5 gm	—	PO	For the treatment of Amoebic dysentery once daily for 3 days.
1.5 gm	1.5 gm	—	PO	For the treatment of Giardiasis once daily for 1-2 days.
500 mg	500 mg	—	PO	For the treatment of Trichomoniasis twice a day for 5 days.
500 mg	500 mg	—	PO	For the treatment of Amoebiasis twice a day for 5-10 days.
Paediatric Dosage (20kg)
10 mg/kg	10 mg/kg	Every 12h	I/V	For 5 to 10 days
25 mg/kg	25 mg/kg	—	Oral	As a single dose
Neonatal Dosage (3kg)
No data.

Drug Interactions

None recorded.

Side Effects

The signs and symptoms that are produced after acute overdosage of Ornidazole are Nausea, fatigue, Headache, Rashes , Vertigo , Insomnia, Pyrosis.

Ornidazole is known to cause more or less tolerable side effects which are usually transient. These include Ataxia, dizziness, Headache, Nausea, Skin rashes, Urticaria, Weakness.

Warnings / Precautions

Special precautions are required in case of ataxia, vertigo, mental confusion and patients with neurological diseases. There is need for adjustment of dosage and dosage interval in patients with hepatic impairment. Modification of the usual dosage is not necessary in patients of renal failure however, additional post haemodialysis dose may be required in patients undergoing this procedure.

Available Brands

None recorded.

Storage Conditions

Ornidazole should be stored Tablets.

Drug Classification

1.6.4.1 — Antiamebic & antigiardiasis drugs