Mephentermine
A sympathomimetic agent with mainly indirect effects on adrenergic receptors. .It has alpha and beta adrenergic activity and a slight stimulating effect on CNS. It has an ionotropic effect on heart. It is used to maintain blood pressure in hypotensive states, for example, following spinal anesthesia. Although the central stimulant effects of mephentermine are much less than those of amphetamine, its use may lead to amphetamine-type dependence.
Primary Characteristics
Mephentermine is also known as Mephentermine Sulphate.
It is of Synthetic origin and belongs to Sulphun.
Molecular Weight: 460.6 · Non-proprietary name: Mephentermine.
Pharmacokinetics
Elimination: it is metabolised via Hepatic, plasma half-life is 15-20 mins, renal excretion is Urine (main).
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Indications
Mephentermine is primarily indicated in conditions like Hypotension, Hypotension during inhalational anesthesia.
Contraindications
Mephentermine is contraindicated in conditions like Cardiovascular disease, Pregnancy, Lactation.
Dosage
Mephentermine's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 22.5 mg | 22.5 mg | — | IM | |
| 45 mg | 45 mg | — | IV | 20 mins prior to anesthesia. |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Mephentermine in overdosage may give rise to further complications which include Convulsions , Tachycardia , Hyperglycemia , Hyperglycemia, Tachycardia.
The signs and symptoms that are produced after acute overdosage of Mephentermine are Tachycardia , Convulsions , Drowsiness, Drowsiness, Hallucinations , Palpitations , Anxiety .
Mephentermine is known to cause more or less tolerable side effects which are usually transient. These include Anxiety, Confusion, Drowsiness, Dyspnea, Hallucination , Headache, Hypertension , Incontinence, Palpitation, Restlessness, Sweating , Tremor.
Warnings / Precautions
Available Brands
None recorded.
Storage Conditions
Drug Classification
- 1.21.4.3 — Sympathomimetics