Meclofenamate

Also known as: Anthranilic acid

Drug #1980

Meclofenamate is a nonsteroidal agent which has demonstrated anti-inflammatory used to treat arthritis, analgesic, and antipyretic activity in laboratory animals.

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Primary Characteristics

Meclofenamate is also known as Anthranilic acid, Meclofenamate Sodium.

It is of Synthetic origin.

Molecular Weight: 336.1 · Solubility in Water: Practically insoluble · Solubility in Alcohol: Slightly soluble · Non-proprietary name: Meclofenamate.

Pharmacokinetics

Distribution: Meclofenamate has a plasma protein binding is greater than 99%.

Elimination: plasma half-life is 2-4 hr.

Indications

Meclofenamate is primarily indicated in conditions like Mild to moderate pain, Osteoarthritis, Rheumatoid arthritis.

Meclofenamate is also indicated for secondary conditions like Primary dysmenorrhea.

Contraindications

Meclofenamate is contraindicated in conditions like Bronchospasm, Urticaria, Allergic rhinitis, Hypersensitivity to the drug.

Dosage

Meclofenamate's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
75 mg	75 mg	—	PO	To maximum of 400mg. 4 or 6 times a day.
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

5 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Meclofenamate produces potentially life-threatening effects which include Renal failure. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Meclofenamate are Edema, Anorexia , Pruritus , Flatulence , Peptic ulcer, Pyrosis.

Meclofenamate is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Constipation , Diarrhea, Nausea, Rashes , Urticaria.

Warnings / Precautions

Patients receiving nonsteroidal anti-inflammatory agents, such as meclofenamate , should be evaluated periodically to insure that the drug is still necessary and well tolerated There is a risk of GI Ulceration, Bleeding and Perforation with Meclofenamate so precautions should be considered. Before taking meclofenamate , tell your doctor if you have a history of high blood pressure, blood disorders, heart disease, gastrointestinal problems, alcoholism, liver disease, or kidney disease. While taking meclofenamate , it is very important for your doctor to monitor your progress through regular visits. Do not take meclofenamate on an empty stomach.

Interference in Pathology

Meclofenamate may interfere in the diagnosis of Serum transaminase levels are elevated., Alkaline phosphatase levels are elevated..

Available Brands

None recorded.

Storage Conditions

Meclofenamate should be stored Tablets.

Drug Classification

1.2.1.3 — Non steroidal anti-inflammatory drugs (NSAIDs)