Lymphocyte Immune Globulin

Drug #1958

Lymphocyte immune globulin is a drug used to suppress the immune system. Lymphocyte immune globulin is also known by the generic name anti-thymocyte globulin (ATG) and the brand names Atgam and Thymoglobulin. Atgam first received FDA approval in 1981 and Thymoglobulin in 1999. As of 2001, no generic preparations are available.

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Primary Characteristics

Molecular Weight: 55.85 · Non-proprietary name: Lymphocyte Immune Globulin.

Molecular structure of Lymphocyte Immune Globulin

Pharmacokinetics

Elimination: plasma half-life is 5.7 hours, renal excretion is 1% in urine.

Indications

Lymphocyte Immune Globulin is primarily indicated in conditions like Aplastic anemia, Rejection of organ transplants.

Lymphocyte Immune Globulin is also indicated for secondary conditions like Non-hodgkin's lymphoma, Non-hodgkin's lymphoma.

Contraindications

Lymphocyte Immune Globulin is contraindicated in conditions like Systemic infections.

Dosage

Lymphocyte Immune Globulin's dosage details are as follows:

Dose	Single Dose	Frequency	Route
Adult Dosage
20 mg/kg	20 mg/kg	—	IV
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

None recorded.

Side Effects

Lymphocyte Immune Globulin in overdosage may give rise to further complications which include Allergic reactions , Confusion , Seizures , Dizziness , Chest pain , Anaphylaxis .

Lymphocyte Immune Globulin is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Chills, Diarrhea, Dyspnoea, Fever, Headache, Hypertension , Hypotension , Joint pain, Muscle pain, Nausea, Peripheral edema, Pruritis, Rash, Urticaria, Vomiting .

Warnings / Precautions

Watch patients carefully for signs of leukopenia,thrombocytopenia or concurrent infections. Dilution of it is not recommended in dextrose injection. Only physicians experienced in immunosuppressive therapy in treatment of renal transplant or aplastic anemia patients should use ATGAM.

Available Brands

None recorded.

Storage Conditions

Lymphocyte Immune Globulin should be stored .

Drug Classification

1.19.2.7 — Antilymphocytic globulin