Flucloxacillin.
Also known as: Floxacillin, Flucloxacillin sodium, Flucloxacillinum, Flucloxacillinic acid
Flucloxacillin is an antibiotic & is used to treat infections caused by susceptible gram Positive bacteria. It is active against Beta-lactamase producing organisms such as staphylococcus accreus. Which would otherwise be resistant to most penicillins.
Primary Characteristics
Flucloxacillin. is also known as Floxacillin, Flucloxacillin sodium, Flucloxacillinum, Flucloxacillinic acid.
It is of Semi Synthetic origin and belongs to Isoxazolyl penicillins.
Molecular Weight: 453.87 · pKa: 2.7 · Solubility in Water: 5.45e-02 g/l · Solubility in Alcohol: 1 in 8 · Non-proprietary name: Flucloxacillin. · pH: 5.
Pharmacokinetics
Absorption: Flucloxacillin. has an oral bioavailability is 60% (±10%).
Distribution: Flucloxacillin. has a volume of distribution is 8-21. plasma protein binding is 95%.
Elimination: it is metabolised via Liver, plasma half-life is 30-60 min, renal excretion is 65.5% (Oral route) 76.1% (Parental route).
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Indications
Flucloxacillin. is primarily indicated in conditions like Cellulitis, Osteomyelitis, Pneumonia, Septicaemia.
Flucloxacillin. is also indicated for secondary conditions like Empyema,.
Contraindications
Flucloxacillin. is contraindicated in conditions like Allergy.
Dosage
Flucloxacillin.'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 500 mg | 500 mg | Every 4h | I/M | |
| 2 g | 2 g | Every 4h | I/V | |
| 500 mg | 500 mg | Every 4h | Oral | |
| Paediatric Dosage (20kg) | ||||
| 50 – 4 mg/kg/day | — | Every 4h | ||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
None recorded.
Side Effects
Flucloxacillin. in overdosage may give rise to further complications which include Hepatitis , Cholestatic jaundice , Cholestatic jaundice , Phlebitis, Neutropenia , Agranulocytosis , Kernectirus in neonates.
Flucloxacillin. produces potentially life-threatening effects which include Pseudomembranous colitis , Anaphylaxis , Bone marrow depression. Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Flucloxacillin. are Nausea, Vomiting, Diarrhea, Porphyria.
Flucloxacillin. is known to cause more or less tolerable side effects which are usually transient. These include Diarrhea, Inflammation, Nausea, Pain , Rashes .
Warnings / Precautions
Interference in Pathology
Flucloxacillin. may interfere in the diagnosis of False increase in urine aminoacids, Interferes in 17-Ketosteroids.
Available Brands
Storage Conditions
Manufacturers
Manufacturers of Flucloxacillin. in Pakistan: