Ioxilan

Drug #1939

Ioxilan is an iodinated nonionic monomeric contrast medium used for various radiographic procedures including enhancement of computed tomography (). It is given by injection.

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Primary Characteristics

Molecular Weight: 791.1 · Solubility in Water: soluble (Non-ionic) · Non-proprietary name: Ioxilan.

Pharmacokinetics

Distribution: Ioxilan has a plasma protein binding is neglible.

Elimination: it is metabolised via No evidence, plasma half-life is 2 hrs, renal excretion is 93.7% unchanged.

Indications

Ioxilan is primarily indicated in conditions like Cerebral angiography, Cerebral arteriography.

Ioxilan is also indicated for secondary conditions like Computed tomography scans.

Contraindications

Ioxilan is contraindicated in conditions like Hypersensitivity to any component of product.

Dosage

Ioxilan's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
67.5 %	67.5 %	—
6 ml	6 ml	—	IA	Coronary Arteriography and Left Ventriculography: Left and Right Coronary:
37.5 ml	37.5 ml	—	IA	Coronary Arteriography and Left Ventriculography: Left ventricle. Total dose for the procedure should not usually exceed 250 mL.
72.5 ml	72.5 ml	—	IA	Peripheral Arteriography: Aortic bifurcation for distal runoff:
150 ml	150 ml	—	IA	Contrast Enhanced Computed Tomography: CECTof the Head: Total dose for the procedure should not usually exceed 200 mL.
320 mgl/ml	320 mgl/ml	—	IV	Intravenous Excretory Urography:
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

Moderate1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Ioxilan in overdosage may give rise to further complications which include Myocardial infarction .

The signs and symptoms that are produced after acute overdosage of Ioxilan are Bradycardia, Hypotension, Diarrhea, Angina pectoris.

Ioxilan is known to cause more or less tolerable side effects which are usually transient. These include Chills, Diarrhea, Dizziness, Fever, Headache, Nausea and vomiting.

Warnings / Precautions

Caution must be exercised in patients with severely impaired renal function, combined renal and hepatic disease, combined renal and cardiac disease, severe thyrotoxicosis, myelomatosis, or anuria, particularly when large doses are administered. Patients receiving contrast agents, and especially those who are medically unstable, must be closely supervised. Diagnostic procedures which involve the use of iodinated intravascular contrast agents should be carried out under the direction of personnel skilled and experienced in the particular procedure to be performed. A fully equipped emergency cart, or equivalent supplies and equipment, and personnel competent in recognizing and treating adverse reactions of all types should always be available. Since severe delayed reactions have been known to occur, emergency facilities and competent personnel should be available for at least 30 to 60 minutes after administration.

Interference in Pathology

Ioxilan may interfere in the diagnosis of Thyroid Function Test.

Available Brands

None recorded.

Storage Conditions

Ioxilan should be stored .

Drug Classification

1.14.2 — Radiocontrast media