Ioxaglate

Drug #1937

Ioxaglate is an iodinated, water soluble, ionic, monoacidic dimeric contrast medium. It is a diagnostic radiopaque medium used in angiography, aortography, urography.

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Primary Characteristics

It belongs to Meglumine.

Molecular Weight: 1464.1 · Non-proprietary name: Ioxaglate.

Pharmacokinetics

Distribution: Ioxaglate has a plasma protein binding is very low.

Elimination: plasma half-life is 90min, renal excretion is 90%.

Indications

Ioxaglate is primarily indicated in conditions like Angiography, Arthrography, Urography.

Ioxaglate is also indicated for secondary conditions like Hysterosalpingography.

Contraindications

Ioxaglate is contraindicated in conditions like Hypersensitivity to any component of product.

Dosage

Ioxaglate's dosage details are as follows:

Dose	Single Dose	Frequency
Adult Dosage
37.5 ml	37.5 ml	—
Paediatric Dosage (20kg)
1.5 ml/kg	1.5 ml/kg	—
Neonatal Dosage (3kg)
No data.

Drug Interactions

1 interaction

Major1 interaction

Moderate4 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Ioxaglate in overdosage may give rise to further complications which include Myocardial infarction .

The signs and symptoms that are produced after acute overdosage of Ioxaglate are Seizures, Thromboembolism, Hypersensitivity reactions.

Ioxaglate is known to cause more or less tolerable side effects which are usually transient. These include Anxiety, Chest pain, Chills, dizziness, Fever, Nausea and vomiting, Rashes , Sweating .

Warnings / Precautions

Diagnostic procedures which involve the use of iodinated intravascular contrast agents should be carried out under the direction of personnel skilled and experienced in the particular procedure to be performed. All procedures utilizing contrast media carry a definite risk of producing adverse reactions. While most reactions are minor, life-threatening and fatal reactions may occur without warning, and this risk must be weighed against the benefit of the procedure. Acute renal failure has been reported in diabetic patients with diabetic nephropathy and in susceptible nondiabetic patients (often elderly with pre-existing renal disease) following the administration of iodinated contrast agents. Therefore, careful consideration of the potential risks should be given before performing this radiographic procedure in these patients.Ioxaglate salts are excreted unchanged in human milk. Because of the potential for adverse effects in nursing infants, bottle feedings should be substituted for breast feedings for 24 hours following the administration of this drug.

Interference in Pathology

Ioxaglate may interfere in the diagnosis of Urinanalysis , Thyroid Function Test, Increased in serum creatinin, Phenolsulfonphthalein (PSP) excretion test.

Available Brands

None recorded.

Storage Conditions

Ioxaglate should be stored .

Drug Classification

1.14.2 — Radiocontrast media