Floxuridine

Also known as: S.Flourodeoxyuridine, SFDU, Deaoxyflourouridine, Flourodeoxycuridine

Drug #1926

Floxuridine is an oncology drug that belongs to class known as "antimetabolites". It's an antineoplastic which acts as an antimetabolite, either by convession to Flourouracil which produces greater inhibition of DNA synthesis

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Primary Characteristics

Floxuridine is also known as S.Flourodeoxyuridine, SFDU, Deaoxyflourouridine, Flourodeoxycuridine.

It belongs to flourinated pyramadine.

Molecular Weight: 246.19 · pK_a: 7.44 · Solubility in Water: 1.19E+004mgh · Non-proprietary name: Floxuridine.

Pharmacokinetics

Elimination: it is metabolised via hepatic, plasma half-life is 20 hr, renal excretion is 10-15% excreted unchanged.

Indications

Floxuridine is primarily indicated in conditions like Colorectal cancer, Gastrointestinal stromal tumour, Neoplasms.

Contraindications

Floxuridine is contraindicated in conditions like Infections, Myelosuppression, Nutrition deficiency.

Dosage

Floxuridine's dosage details are as follows:

Dose	Single Dose	Frequency	Route
Adult Dosage
100 – 600 ug/kg	—	—	Hepatic Orterial Infusion
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

2 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Floxuridine in overdosage may give rise to further complications which include Allergic reactions , Bleeding , Fatigue .

Floxuridine produces potentially life-threatening effects which include Cirrhosis of the liver. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Floxuridine are Nausea, Vomiting, Diarrhea, GI ulceration, Bone marrow depression.

Floxuridine is known to cause more or less tolerable side effects which are usually transient. These include Erythema, Itching, Myocardial Ischemia, Nausea and vomiting, Rashes , Stomach cramping, Stomatitis.

Warnings / Precautions

Floxuridine should not be given to allergic patients. Floxuridine should be given only under the supervision of qualified doctor experienced in cancer chemotherapy. Due to severe toxic effects all patients should be hospitalized for initial course of therapy. aoid contact with people having cold,fluor any contageous illness and also who have been vaccinated with live vaccine recently. Should be used with caution in impaired Kidney & renal function

Interference in Pathology

Floxuridine may interfere in the diagnosis of Periodic blood count, Increased Serum Alkaline Phosphatase, Interferes with BSP, prothrombin & sedimentation rate assays, Thromp openia.

Available Brands

None recorded.

Storage Conditions

Floxuridine should be stored .

Drug Classification

1.8.2 — Cytotoxic (anti-neoplastic) drugs