Estramustine

Also known as: Estramustine Sodium Phosphate, Estracyte, Estramustinum

Drug #1909

Estramustine is a cancer (antineoplastic) medication. Estramustine interferes with the growth and spread in the body. Estramustine used to treat prostate cancer.

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Primary Characteristics

Estramustine is also known as Estramustine Sodium Phosphate, Estracyte, Estramustinum.

It is of Synthetic origin and belongs to Estrogen.

Molecular Weight: 440.4 · Solubility in Water: readily Sluble · Non-proprietary name: Estramustine.

Pharmacokinetics

Elimination: plasma half-life is 20hrs.

Indications

Estramustine is primarily indicated in conditions like Palliative surgery., Prostate cancer.

Estramustine is also indicated for secondary conditions like Metastatic, Prostatic cancer.

Contraindications

Estramustine is contraindicated in conditions like Thrombophlebitis, Thrombo-embolic complications, Hypersensitivity to any component of product.

Dosage

Estramustine's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
560 – 840 mg	—	—	oral	Initial Dose
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Estramustine in overdosage may give rise to further complications which include Thrombocytopenia , Confusion , Chest pain , Hepatic dysfunction.

Estramustine produces potentially life-threatening effects which include Hypertension, Leukopenia, Thromboembolism. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Estramustine are Nausea, Vomiting, Mylosuppresion.

Estramustine is known to cause more or less tolerable side effects which are usually transient. These include Itching, Loss of appetite, Loss of libido, Nausea, Rashes , Tiredness .

Warnings / Precautions

Should be used with caution in patients with the history of thrombophlebitis, thrombosis, thromboembolicn disorders. Because hypertension may occur bloodpressure should be monitored periodically. Patients with prostate cancer and osteoblastic metastases are at risk for hypocalcemia and should have calcium levels closely monitored.

Interference in Pathology

Estramustine may interfere in the diagnosis of Abnormal LFTs .

Available Brands

None recorded.

Storage Conditions

Estramustine should be stored Drug Form.

Drug Classification

1.8.5 — Drugs used in Palliative care