Enalaprilat
Also known as: ACE-inhibitor
Enalaprilat is the first dicarboxylate containing ACE inhibitor,developed partially to overcome limitations of captopril.It works by helping to relax blood vessels and thus helps in reducing blood pressure.
Primary Characteristics
Enalaprilat is also known as ACE-inhibitor.
Molecular Weight: 384.4 · Solubility in Water: very sligthly · Solubility in Alcohol: Sparingaly soluble · Non-proprietary name: Enalaprilat.
Pharmacokinetics
Distribution: Enalaprilat has a plasma protein binding is 50-60%.
Elimination: plasma half-life is 11 hours, renal excretion is 90% through urine.
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Indications
Enalaprilat is primarily indicated in conditions like Hypertension, Left ventricular dysfunction.
Enalaprilat is also indicated for secondary conditions like Heart failure.
Contraindications
Enalaprilat is contraindicated in conditions like Pregnancy.
Dosage
Enalaprilat's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 15 mg | 15 mg | — | oral | |
| 1.25 mg | 1.25 mg | — | parenteral | |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
None recorded.
Side Effects
The signs and symptoms that are produced after acute overdosage of Enalaprilat are Hypotension, fatigue, Dizziness, Headache, Dry cough, Deafness .
Enalaprilat is known to cause more or less tolerable side effects which are usually transient. These include Hypotension , Itching, Loss of taste, Rashes .
Warnings / Precautions
Interference in Pathology
Enalaprilat may interfere in the diagnosis of Liver Function Test (LFT) , Increased in serum creatinin.
Available Brands
None recorded.
Storage Conditions
Drug Classification
- 1.12.3.3 — ACE inhibitors