Acetohexamide
Also known as: Acetohexamid
Acetohexamide is a first generation sulfonylurea medication used to treat Diabetes mellitus type-2,particularly in people whose diabetes cannot be controlled by diet alone.
Primary Characteristics
Acetohexamide is also known as Acetohexamid.
It is of Synthetic origin.
Molecular Weight: 324.4 · Solubility in Water: Insoluble · Solubility in Alcohol: Soluble 1 in 230 of alcohol · Non-proprietary name: Acetohexamide.
Pharmacokinetics
Distribution: Acetohexamide has a plasma protein binding is 90%.
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Indications
Acetohexamide is primarily indicated in conditions like Diabetes mellitus type-ii.
Contraindications
Acetohexamide is contraindicated in conditions like Hypersensitivity, Pregnancy, Insulin dependent diabetes mellitus.
Dosage
Acetohexamide's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 1 mg | 1 mg | — | PO | Initially 250mg before Breakfast then increased by 250-500mg at in level of 5-7 days to a maintanance dose up to 1.5 gm/day. For doses above 1 gm/day give in two divided doses. Before morning and evening meal. |
| 487.5 mg prn q 4-6hrs | 487.5 mg prn q 4-6hrs | — | PO | |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Acetohexamide is known to cause more or less tolerable side effects which are usually transient. These include Breathlessness , Fever, Hypoglycemia, Skin reactions.
Warnings / Precautions
Available Brands
None recorded.
Storage Conditions
Drug Classification
- 1.18.7.2 — Oral hypoglycemics