Iodixanol

Drug #1888

Iodixanol is a radiopaque agent used to diagnose certain medical conditions.It is usually only given in a clinic or hospital.It contains iodine,it can be used to take pictures of the blood vessels around your heart ,brain,kidney or other structure in the body.

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Primary Characteristics

It is of Synthetic origin.

Molecular Weight: 1550.2 · Solubility in Water: freely soluble · Non-proprietary name: Iodixanol.

Pharmacokinetics

Distribution: Iodixanol has a volume of distribution is 0.26L/kg. plasma protein binding is 0%.

Elimination: plasma half-life is 2 hours, renal excretion is 97%.

Indications

Iodixanol is primarily indicated in conditions like Angiography, Arteriography, Hysterosalpingography, Myelography, Urography, Venography.

Iodixanol is also indicated for secondary conditions like Computed tomography scans.

Contraindications

Iodixanol is contraindicated in conditions like Renal impairment, Hypersensitivity to any component of product.

Dosage

Iodixanol's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
1 ml/kg of body weight	1 ml/kg of body weight	—	IV	Excretory Urography: Intravenous, 1 mL per kg of body weight of a solution containing the equivalent of 270 or 320 mg of iodine per mL . Maximum 100 ml.
100 ml	100 ml	—	IV	Venography: Intravenous, 50 to 150 mL per lower extremity of a solution containing the equivalent of 270 mg of iodine per mL
112.5 ml	112.5 ml	—	IV	Brain imaging or body imaging, computed tomography or Intravenous, by bolus injection, 75 to 150 mL of a solution containing the equivalent of 270 or 320 mg of iodine per mL; or by intravenous infusion, 100 to 150 mL of a solution containing the equivalent of 270 or 320 mg of iodine per mL
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

None recorded.

Side Effects

Iodixanol in overdosage may give rise to further complications which include Hypotension , Hypotension , Syncope , Edema, Cardiac arrest , Irregular heart beat, Paralysis, Rigors.

Iodixanol is known to cause more or less tolerable side effects which are usually transient. These include Chest pain, Chills, Fever, Headache, Nausea.

Warnings / Precautions

Intrathecal use of Iodixanol results in serious adverse events including death. It should not be given to a child who has recently used a laxative (stool softener) or has not eaten properly before the test. It is not known whether iodixanol passes into breast milk or if it could harm a nursing baby. Older adults may need special care in avoiding dehydration by drinking extra fluids before and after the radiologic test. Kidney function may also need to be watched closely after iodixanol administration. It is a nonionic dimeric iodionated radiographic contract medium.

Interference in Pathology

Iodixanol may interfere in the diagnosis of Urinanalysis , Thyroid Function Test.

Available Brands

Click on a strength to view available brands.

Single Ingredient

Inj

270 mg/ml 320 mg/ml

Storage Conditions

Iodixanol should be stored .

Drug Classification

1.14.2 — Radiocontrast media

Manufacturers

Manufacturers of Iodixanol in Pakistan:

Meximp