Insulin
Also known as:
Insulin is a hormone which is proteinic in nature. It is secreted by a group of cells called islet cells within the pancreas. Insulin is used medically to treat some forms of diabetes mellitus. Insulin from animal source differs some what in regulatory function strength in humans because of variations.Procine insulin is especially close to the human version. Macleod and Banting were awarded the NOBLE PRIZE in physiology in 1923 for discovery of insulin.
Primary Characteristics
Insulin is also known as .
It is of Natural origin.
It belongs to Insulin agonist pharmacological group on the basis of mechanism of action and also classified in Antidiabetic Agent, Insulin pharmacological group.
Molecular Weight: 6000 · pKa: 5.39 · Solubility in Water: slightly · Non-proprietary name: Insulin.
Pharmacokinetics
Elimination: renal excretion is 2%.
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Indications
Insulin is primarily indicated in conditions like Diabetes insipidus, Diabetes mellitus.
Insulin is also indicated for secondary conditions like Adjunct in GI-disorders, Myocardial infarction, Stroke.
Contraindications
Insulin is contraindicated in conditions like Hypoglycaemia, Hypersensitivity to any component of product.
Dosage
Insulin's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 500 U/ml | 500 U/ml | — | IV | |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Insulin in overdosage may give rise to further complications which include Blurred vision , Hypokalemia , Allergy , Hypoglycemia, Hyperglycemia .
Insulin produces potentially life-threatening effects which include Convulsions . Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Insulin are Weakness , Headache, Hypotension, Dyspnea, Fainting .
Insulin is known to cause more or less tolerable side effects which are usually transient. These include Rashes , Redness, Swelling .
Warnings / Precautions
Interference in Pathology
Insulin may interfere in the diagnosis of Monitoring of blood and urine glucose.
Available Brands
Drug Classification
- 1.18.7.1 — Insulins