Sildenafil
Also known as: viagra
Sildenafil is a selective inhibitor of phosphodiesterase.It is develop in 1991 as a treatment for angina.Now it is marketed under the name of VIAGRA for the treatment of impotence since 1998.
Primary Characteristics
Sildenafil is also known as viagra.
It is also classified under Antihypertensive Agents .
Molecular Weight: 666.7 · Non-proprietary name: Sildenafil.
Pharmacokinetics
Absorption: Sildenafil has an oral bioavailability is 20% (±20%).
Distribution: Sildenafil has a volume of distribution is 105 litres. plasma protein binding is 96%.
Elimination: it is metabolised via hepatic, plasma half-life is 3-4 hours, renal excretion is 13%.
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Indications
Sildenafil is primarily indicated in conditions like Angina pectoris, Erectile dysfunction, Hypertension.
Sildenafil is also indicated for secondary conditions like Oesophageal motility disorders, Priapism, Pulmonary hypertension, Raynaud`s phenomenon.
Contraindications
Sildenafil is contraindicated in conditions like Myocardial infarction, Peptic ulcer, Congestive heart failure, Hypotension, Unstable angina, Renal impairment, Hepatic impairment, Coagulation disorder, Retinal damage, Stroke, Arrhythmias.
Dosage
Sildenafil's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 75 mg | 75 mg | Every 24h | oral | The dose is reduced to 25 mg in elderly and in patients with hepatic or renal impairment or patients taking CYP450 inhibitors |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Sildenafil in overdosage may give rise to further complications which include Hypotension , Ventricular arrhythmia.
Sildenafil produces potentially life-threatening effects which include Myocardial infarction, Sudden death, Stroke. Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Sildenafil are Dyspepsia, Gastritis, Diarrhea.
Sildenafil is known to cause more or less tolerable side effects which are usually transient. These include Diarrhea, Dizziness, Dyspepsia , Flushing, Headache, Nasal congestion , Photophobia , Pulse irregularities, Sneezing, Vison disturbance, Vomiting .
Warnings / Precautions
Available Brands
None recorded.
Storage Conditions
Drug Classification
- 1.29 — Drugs used in renal, bladder, and prostatic disorders