Doxacurium

Also known as: Isoquinolinium dichloride

Drug #1850

Doxacurium chloride is a long-acting, nondepolarizing skeletal muscle relaxant. The neuromuscular block produced by doxacurium chloride may be antagonized by anticholinesterase agents. As with other nondepolarizing neuromuscular blocking agents, the more profound the neuromuscular block at reversal, the longer the time and the greater the dose of anticholinesterase required for recovery of neuromuscular function. Doxacurium chloride is approximately 2.5 to 3 times more potent than pancuronium and 10 to 12 times more potent than metocurine. Doxacurium chloride binds competitively to cholinergic receptors on the motor end-plate to antagonize the action of acetylcholine, resulting in a block of neuromuscular transmission. This action is antagonized by acetylcholinesterase inhibitors, such as neostigmine.

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Primary Characteristics

Doxacurium is also known as Isoquinolinium dichloride, Doxacurium Chloride.

It is of Synthetic origin and belongs to Isoquinolinium.

It belongs to Anticholinesterase agent pharmacological group on the basis of mechanism of action and also classified in Neuromuscular Blocking Agent, Nondepolarizing pharmacological group.

Molecular Weight: 1106.14 · Non-proprietary name: Doxacurium.

Pharmacokinetics

Distribution: Doxacurium has a plasma protein binding is 30%.

Elimination: plasma half-life is 99 min, renal excretion is Clearance 2.7 ml/kg/min.

Indications

Doxacurium is primarily indicated in conditions like Adjunct to anesthesia, Painful musculoskeletal conditions.

Contraindications

Doxacurium is contraindicated in conditions like Hypersensitivity to the drug.

Dosage

None recorded.

Drug Interactions

Major1 interaction

Moderate5 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Doxacurium in overdosage may give rise to further complications which include Dizziness , Fever , Wheezing , Hives, Muscular weakness .

Doxacurium is known to cause more or less tolerable side effects which are usually transient. These include Apnea , Flushing, Light headedness, Pain , Redness, Respiratory insufficiency, Skeletal muscle paralysis.

Warnings / Precautions

Should be administered in carefully adjusted dosage by or under the supervision of experienced clinicians who are familiar with the drug's actions and the possible complications of its use. The drug should not be administered unless facilities for intubation, artificial respiration, oxygen therapy, and an antagonist are within immediate reach. It is recommended that clinicians administering long-acting neuromuscular blocking agents employ a peripheral nerve stimulator to monitor drug response, need for additional relaxants, and adequacy of spontaneous recovery or antagonism.

Available Brands

None recorded.

Drug Classification

1.1.4 — Muscle relaxants and cholinesterase inhibitors
2.20 — Muscle relaxants and cholinesterase inhibitors