Pemetrexed

Drug #1836

Pemetrexed is an anti-cancer chemotherapy drug. It is classified as an antimetabolite. It is used in the treatment of malignant mesothelioma.

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Primary Characteristics

Non-proprietary name: Pemetrexed.

Pharmacokinetics

None recorded.

Indications

Pemetrexed is primarily indicated in conditions like Mesothelioma, Non-small cell lung carcinoma.

Contraindications

Pemetrexed is contraindicated in conditions like Thrombocytopenia, Renal diseases, Pregnancy, Lactation.

Dosage

Pemetrexed's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
500 mg/m2	500 mg/m2	—	IV	Pemetrexed is given in the form of Pemetrexed disodium infused over 10 min on day 1 of each 21-day cycle.
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

2 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Pemetrexed is known to cause more or less tolerable side effects which are usually transient. These include Anemia, Anorexia , Chest pain, Constipation , Depression, Fatigue, Fever, Increase in blood test creatinine, Leucopenia, Low platelet count, Mouth ulcers, Nausea and vomiting, Numbness , Tingling of the hand.

Warnings / Precautions

Before starting premetrexed treatment, make sure you tell your doctor about any other medications you are taking (including prescription, over-the-counter, vitamins, herbal remedies, etc.). Do not take aspirin, or products containing aspirin unless your doctor specifically permits this. Do not take non-steroidal anti-inflammatory drugs (NSAIDS) such as ibuprophen unless your doctor specifically permits this. Do not receive any kind of immunization or vaccination without your doctor's approval while taking premetrexed. Inform your health care professional if you are pregnant or may be pregnant prior to starting this treatment. Pregnancy category D (premetrexed may be hazardous to the fetus. Women who are pregnant or become pregnant must be advised of the potential hazard to the fetus.) For both men and women: Do not conceive a child (get pregnant) while taking premetrexed. Do not breast feed while taking this medication.

Interference in Pathology

Pemetrexed may interfere in the diagnosis of Elevation in ALT or AST.

Available Brands

Click on a strength to view available brands.

Single Ingredient

Inj

100 mg 500 mg

Drug Classification

1.8.2 — Cytotoxic (anti-neoplastic) drugs

Manufacturers

Manufacturers of Pemetrexed in Pakistan:

Haji Lilly