DrugInfoSys

Aripiprazole

Drug #1823

Atypical antipsychotic, having less axtrapyramidal symptoms than older antipsychotics. It is used to treat schizophrenia. Atypical antipsychotics should be used with caution in patients with cardiovascular disease, or a history of epilepsy.

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Primary Characteristics

It is of Synthetic origin.

Molecular Weight: 448.39 · Solubility in Water: 7.77e-03mg/mL · Non-proprietary name: Aripiprazole.

Molecular structure of Aripiprazole

Pharmacokinetics

Distribution: Aripiprazole has a volume of distribution is 40L or 4.9L/kg. plasma protein binding is >99%.

Elimination: it is metabolised via liver, plasma half-life is 75-146hrs.

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Indications

Aripiprazole is primarily indicated in conditions like Schizophrenia.

Contraindications

Aripiprazole is contraindicated in conditions like Breast feeding.

Dosage

Aripiprazole's dosage details are as follows:

DoseSingle DoseFrequencyRouteInstructions
Adult Dosage
15 – 30 mg—Every 24hPO
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown1 interaction
1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Aripiprazole is known to cause more or less tolerable side effects which are usually transient. These include Akathisia, Asthenia , Blurred vision, Constipation , Dyspepsia , Headache, Insomnia, Light headedness, Nausea, Postural hypotension, Seizures, Somnolence , Tachycardia, Tremor, Vomiting .

Warnings / Precautions

While atypical antipsychotics have not generally been associated with clinical significant prolongation of the QT interval, they should be used with care if prescribed with other drugs that increase the QT interval. It should be used with caution in patients with cardiovascular disease, or a history of epilepsy; they should be used with caution in the elderly. It may affect performance of skilled tasks (e.g. driving). Withdrawal of antipsychotic drugs after long-term therapy should always be gradual and closely monitored to avoid the risk of acute withdrawal syndromes or rapid relapse.

Available Brands

Click on a strength to view available brands.

Single Ingredient

Tabs
10 mg15 mg20 mg30 mg5 mg

Storage Conditions

Aripiprazole should be stored Tablets,solutions.

Drug Classification

  1. 1.24.1 — Drugs used in psychotic disorders

Manufacturers