Clobazam
Clobazam is antiepileptic drug. Clobazam is less sedative. Chemically Clobazam is 7-chloro-1-methyl-5-phenyl-1H-1, 5-benzodiazipine-2, 4(3H, 5H)-dione. A minor tranquilizer.
Primary Characteristics
It is of Synthetic origin and belongs to Benzodiazepines.
It belongs to Chloride Channel Potentiater (GABA operated) pharmacological group on the basis of mechanism of action and also classified in Benzodiazepine pharmacological group. It is also classified under Sedatives and Hypnotics .
Molecular Weight: 300.7 · pKa: < 6 · Solubility in Water: 1 in 10000 · Solubility in Alcohol: 1 in 50 · Non-proprietary name: Clobazam.
Pharmacokinetics
Absorption: Clobazam has an oral bioavailability is 97% (±2%).
Distribution: Clobazam has a volume of distribution is 0.9 l/kg. plasma protein binding is 90%.
Elimination: it is metabolised via hepatic, plasma half-life is 10-50 hr, renal excretion is 97%.
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Indications
Clobazam is primarily indicated in conditions like Adjunct in epilepsy, Anxiety states in psychotic disorders, Epilepsy, Primary anxiety, Sleep disturbances, Suppression of transplant rejection.
Contraindications
None recorded.
Dosage
Clobazam's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 25 mg | 25 mg | — | PO | Usually in divided doses. Max dose 60 mg. |
| Paediatric Dosage (20kg) | ||||
| 0.415 mg/kg | 0.415 mg/kg | Every 8h | Oral | |
| Neonatal Dosage (3kg) | ||||
| 0.6 mg/kg | 0.6 mg/kg | Every 12h | oral | |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Clobazam in overdosage may give rise to further complications which include Drug dependence .
Clobazam produces potentially life-threatening effects which include Blood dyscrasias. Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Clobazam are Emesis, Muscular weakness.
Clobazam is known to cause more or less tolerable side effects which are usually transient. These include Amnesia , Ataxia, Dizziness, Drowsiness, Dry mouth, Headache, Light headedness, Nausea, Paradoxical effects, Weakness.
Warnings / Precautions
Available Brands
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Single Ingredient
Storage Conditions
Drug Classification
- 1.24.3 — Drugs used in anxiety and sleep disorders