Sodium Aurothiomalate

Drug #1797

Sodium Aurothiomalate is a gold compound which is among the disease modifying antirheumatic drugs (DMARDs). Sodium Aurothiomalate is used mainly for its anti-inflammatory effect in active progressive rheumatoid arthritis and progressive juvenile chronic arthritis; they may also be beneficial in psoriatic arthritis. They are generally reserved for use as second line drugs in patients whose symptoms are unresposive to or inadequately controlled by NSAIDs alone. Gold compounds suppress and prevent but do not cure arthritis. A patient should be warned to tell doctor immediately if sore throat, fever, infection. unexplained bleeding and bruising, mouth ulcers, skin rashes, edema, and metallic taste develop. If toxicity develops, gold therapy should be discontinued immediately.

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Primary Characteristics

It is of Synthetic origin.

Non-proprietary name: Sodium Aurothiomalate.

Molecular structure of Sodium Aurothiomalate

Pharmacokinetics

None recorded.

Indications

Sodium Aurothiomalate is primarily indicated in conditions like Reversal of non-depolarisisng neuromuscular blockade, Small cell carcinoma.

Contraindications

Sodium Aurothiomalate is contraindicated in conditions like Pulmonary fibrosis, Bone marrow aplasia, Haematological disorders, Hypersensitivity to any component of product.

Dosage

Sodium Aurothiomalate's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
10 mg	10 mg	—	IM	INITIAL DOSE: 10 mg is for 1st week.25 mg the second week, then 25 to 50 mg weekly for the next 20 weeks or until toxicity occurs.
50 mg	50 mg	—	IM	MAINTANANCE DOSE: 50 mg i.m. tapered progressively to every 2 to 4 weeks according to clinical response and tolerance, and maintained indefinitely.
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

None recorded.

Side Effects

Sodium Aurothiomalate is known to cause more or less tolerable side effects which are usually transient. These include Alopecia, Blood disorders, Cholestatic Jaundice , Colitis, Hepatotoxicity, Mouth ulcers, Nephrotic toxicity, Proteinuria , Pulmonary firbrosis, Skin reactionsX.

Warnings / Precautions

Sodium aurothiomalate should be administered only to selected patients who are under the supervision of a physician experienced with chrysotherapy and thoroughly familiar with the toxicity and benefits of the drug.Toxic reactions to sodium aurothiomalate are relatively frequent and, in certain cases, may be quite severe. Thus emphasis should be placed on careful clinical and laboratory monitoring and early detection of adverse reactions.

Available Brands

None recorded.

Storage Conditions

Sodium Aurothiomalate should be stored Inj.

Drug Classification

1.2.4 — Disease modifying antirheumatic drugs