Lutropin Alfa
Lutropin Alfa is a recombinant DNA-derived human luteinising hormone (LH). LH is a gonadotrophin, secreted by the anterior lobe of pituitary, along with another gonadotrophin, follicle-stimulating hormone (FSH). It stimulates the normal functioning of the gonads and the secretion of sex hormones in both men and women. The recombinant form of LH (lutropin alpha), is used in combination with follicle-stimulating hormone (FSH), for the treatment of infertility chiefly in femles but also in males with proven hypopituitarism.
Primary Characteristics
Non-proprietary name: Lutropin Alfa.
Pharmacokinetics
Absorption: Lutropin Alfa has an oral bioavailability is 30% (±30%).
Elimination: plasma half-life is 10-12 hr.
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Indications
Lutropin Alfa is primarily indicated in conditions like Infertility, Superovulation.
Lutropin Alfa is also indicated for secondary conditions like Hypogonadotrophic hypogonadism.
Contraindications
Lutropin Alfa is contraindicated in conditions like Undiagnosed vaginal bleeding, Mild to moderate skin and soft tissue infections, Prophylaxis and long term treatment of recurrent UTIs.
Dosage
Lutropin Alfa's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 75 units | 75 units | Every 24h | SC | Should be coadministered with follitropin alfa as 2 separate injections. For 7-14 days. |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
None recorded.
Side Effects
Lutropin Alfa is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Breast pain, Dysmenorrhea, Ectopic pregnancy, Headache, Injection-site reactions, Nausea and vomiting, Ovarian cyst, Ovarian hyperstimulation syndrome, Somnolence .
Warnings / Precautions
Available Brands
None recorded.
Drug Classification
- 1.18.6 — Ovulation stimulants