Sertindole

Drug #1744

Sertindole is an antipsychotic drug that is an antagonist at central dopamine, serotonin, and adrenergic receptors. It was used in the treatment of schizophrenia, but its marketing was suspended due to cardiac arryhthmias and cardiac deaths associated with its use.

← Previous drug Next drug →

Primary Characteristics

It is of Synthetic origin.

Non-proprietary name: Sertindole.

Pharmacokinetics

Elimination: plasma half-life is 3 days.

Indications

Sertindole is primarily indicated in conditions like Schizophrenia.

Contraindications

Sertindole is contraindicated in conditions like Pregnancy, Breast feeding, Treatment of pulmonary embolism.

Dosage

None recorded.

Drug Interactions

4 interactions

Major1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Sertindole is known to cause more or less tolerable side effects which are usually transient. These include Abnormal ejaculation, Dizziness, Dry mouth, Dyspnea, Extra pyramidal symptoms, Paresthesias, Postural hypotension, Rhinitis , Seizures.

Warnings / Precautions

Sertindole should be used with caution in patients with hepatic impairmen (slower titration and lower maintenance dose in mild to moderate hepatic impairment; avoid in severe); diabetes;correct hypokalaemia or hypomagnesaemia before treatment. Caution is also required in patients with cardiovascular disease, monitor blood pressure during dose titration and early maintenance therapy (risk of postural hypotension); history of epilepsy; it should be used with caution in the elderly. DRIVING: Drowsiness may affect performance of skilled tasks (e.g driving or operating machinery), especially at start of treatment; effects of alcohol are enhanced. WITHDRAWL: Withdrawl of antipsychotic drugs after long-term therapy should always be gradual and closely monitored to avoid the risk of acute withdrawl syndrome or rapid relapse.

Available Brands

None recorded.

Storage Conditions

Sertindole should be stored .

Drug Classification

1.24.1 — Drugs used in psychotic disorders